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Prenatal diethylstilbestrol exposure and human genital tract abnormalities.

Publication ,  Journal Article
Herbst, AL; Scully, RE; Robboy, SJ
Published in: Natl Cancer Inst Monogr
May 1979

The incidence of clear cell adenocarcinoma of the vagina and cervix associated with intrauterine exposure to DES and similar compounds during the first half of pregnancy has increased. Ninety percent of these cancers have occurred in patients 14 years of age or older. Although these carcinomas are exceedingly rare, nonneoplastic abnormalities including vaginal adenosis, cervical eversion (ectropion), and transverse cervical and vaginal ridges are frequent in the exposed population, particularly if the drug was administered early in pregnancy. Current evidence favors a disturbance in development of the müllerian duct as the explanation of these changes. Whether DES is only a teratogen or also a carcinogen is unknown, as is the possible role of other factors in the development of cancer. An increased incidence of cancer among exposed males has not been documented.

Duke Scholars

Published In

Natl Cancer Inst Monogr

ISSN

0083-1921

Publication Date

May 1979

Issue

51

Start / End Page

25 / 35

Location

United States

Related Subject Headings

  • Vaginal Neoplasms
  • Vagina
  • Uterine Cervical Neoplasms
  • Pregnancy
  • Metaplasia
  • Maternal-Fetal Exchange
  • Male
  • Humans
  • Gestational Age
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Herbst, A. L., Scully, R. E., & Robboy, S. J. (1979). Prenatal diethylstilbestrol exposure and human genital tract abnormalities. Natl Cancer Inst Monogr, (51), 25–35.
Herbst, A. L., R. E. Scully, and S. J. Robboy. “Prenatal diethylstilbestrol exposure and human genital tract abnormalities.Natl Cancer Inst Monogr, no. 51 (May 1979): 25–35.
Herbst AL, Scully RE, Robboy SJ. Prenatal diethylstilbestrol exposure and human genital tract abnormalities. Natl Cancer Inst Monogr. 1979 May;(51):25–35.
Herbst, A. L., et al. “Prenatal diethylstilbestrol exposure and human genital tract abnormalities.Natl Cancer Inst Monogr, no. 51, May 1979, pp. 25–35.
Herbst AL, Scully RE, Robboy SJ. Prenatal diethylstilbestrol exposure and human genital tract abnormalities. Natl Cancer Inst Monogr. 1979 May;(51):25–35.

Published In

Natl Cancer Inst Monogr

ISSN

0083-1921

Publication Date

May 1979

Issue

51

Start / End Page

25 / 35

Location

United States

Related Subject Headings

  • Vaginal Neoplasms
  • Vagina
  • Uterine Cervical Neoplasms
  • Pregnancy
  • Metaplasia
  • Maternal-Fetal Exchange
  • Male
  • Humans
  • Gestational Age
  • Female