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Design and preliminary observations of National Cooperative Diethylstilbestrol Adenosis (DESAD) Project.

Publication ,  Journal Article
Labarthe, D; Adam, E; Noller, KL; O'Brien, PC; Robboy, SJ; Tilley, BC; Townsend, D; Barnes, AB; Kaufman, RH; Decker, DG; Fish, CR; Herbst, AL ...
Published in: Obstet Gynecol
April 1978

The National Cooperative Diethylstilbestrol Adenosis (DESAD) Project has completed the major portion of its enrollment phase with the examination of more than 3000 daughters of women taking synthetic nonsteroidal estrogens (denoted DES) during pregnancies occurring from the early 1940s to the mid-1960s. The aims of the Project are to fill urgent needs for information on the prevalence and incidence of structural and epithelial abnormalities or neoplastic changes and their complications in these young women. Participants are grouped by mode of entry as identified by prenatal record review (40.1%), documented as DES-exposed but walking in (25.1%), or referred (22.8%) to the DESAD Project for examination, and not documented as exposed but having gynecologic abnormalities typical of those associated with DES exposure (12.0%). This study cohort, in part having paired controls, will be examined annually for at least 5 years. Details of the design and selected preliminary findings are reported.

Duke Scholars

Published In

Obstet Gynecol

DOI

ISSN

0029-7844

Publication Date

April 1978

Volume

51

Issue

4

Start / End Page

453 / 458

Location

United States

Related Subject Headings

  • Vaginal Neoplasms
  • Vaginal Diseases
  • Vagina
  • United States
  • Research Design
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • National Institutes of Health (U.S.)
  • Humans
  • Follow-Up Studies
 

Citation

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Labarthe, D., Adam, E., Noller, K. L., O’Brien, P. C., Robboy, S. J., Tilley, B. C., … Kurland, L. T. (1978). Design and preliminary observations of National Cooperative Diethylstilbestrol Adenosis (DESAD) Project. Obstet Gynecol, 51(4), 453–458. https://doi.org/10.1097/00006250-197804000-00014
Labarthe, D., E. Adam, K. L. Noller, P. C. O’Brien, S. J. Robboy, B. C. Tilley, D. Townsend, et al. “Design and preliminary observations of National Cooperative Diethylstilbestrol Adenosis (DESAD) Project.Obstet Gynecol 51, no. 4 (April 1978): 453–58. https://doi.org/10.1097/00006250-197804000-00014.
Labarthe D, Adam E, Noller KL, O’Brien PC, Robboy SJ, Tilley BC, et al. Design and preliminary observations of National Cooperative Diethylstilbestrol Adenosis (DESAD) Project. Obstet Gynecol. 1978 Apr;51(4):453–8.
Labarthe, D., et al. “Design and preliminary observations of National Cooperative Diethylstilbestrol Adenosis (DESAD) Project.Obstet Gynecol, vol. 51, no. 4, Apr. 1978, pp. 453–58. Pubmed, doi:10.1097/00006250-197804000-00014.
Labarthe D, Adam E, Noller KL, O’Brien PC, Robboy SJ, Tilley BC, Townsend D, Barnes AB, Kaufman RH, Decker DG, Fish CR, Herbst AL, Gundersen J, Kurland LT. Design and preliminary observations of National Cooperative Diethylstilbestrol Adenosis (DESAD) Project. Obstet Gynecol. 1978 Apr;51(4):453–458.
Journal cover image

Published In

Obstet Gynecol

DOI

ISSN

0029-7844

Publication Date

April 1978

Volume

51

Issue

4

Start / End Page

453 / 458

Location

United States

Related Subject Headings

  • Vaginal Neoplasms
  • Vaginal Diseases
  • Vagina
  • United States
  • Research Design
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • National Institutes of Health (U.S.)
  • Humans
  • Follow-Up Studies