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Sodium-independent binding of L-[3H]proline to hippocampal synaptic membranes.

Publication ,  Journal Article
Greene, WM; Wang, A; Nadler, JV
Published in: Eur J Pharmacol
November 4, 1986

L-[3H]Proline binds specifically and saturably to rat hippocampal synaptic membranes in the absence of inorganic ions. Saturation isotherms constructed in Hepes-Tris buffer best fit a model of a single independent population of binding sites with a dissociation constant of 1.6 microM and maximum density of 16 pmol/mg protein. The rank order of displacement of radioligand by proline analogues suggests that binding sites of this type could be receptors responsible for proline-induced retinal spreading depression and inhibition of memory consolidation.

Duke Scholars

Published In

Eur J Pharmacol

DOI

ISSN

0014-2999

Publication Date

November 4, 1986

Volume

130

Issue

3

Start / End Page

333 / 336

Location

Netherlands

Related Subject Headings

  • Synaptic Membranes
  • Sodium
  • Rats, Inbred Strains
  • Rats
  • Proline
  • Pharmacology & Pharmacy
  • Kinetics
  • In Vitro Techniques
  • Hippocampus
  • Female
 

Citation

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Greene, W. M., Wang, A., & Nadler, J. V. (1986). Sodium-independent binding of L-[3H]proline to hippocampal synaptic membranes. Eur J Pharmacol, 130(3), 333–336. https://doi.org/10.1016/0014-2999(86)90288-8
Greene, W. M., A. Wang, and J. V. Nadler. “Sodium-independent binding of L-[3H]proline to hippocampal synaptic membranes.Eur J Pharmacol 130, no. 3 (November 4, 1986): 333–36. https://doi.org/10.1016/0014-2999(86)90288-8.
Greene WM, Wang A, Nadler JV. Sodium-independent binding of L-[3H]proline to hippocampal synaptic membranes. Eur J Pharmacol. 1986 Nov 4;130(3):333–6.
Greene, W. M., et al. “Sodium-independent binding of L-[3H]proline to hippocampal synaptic membranes.Eur J Pharmacol, vol. 130, no. 3, Nov. 1986, pp. 333–36. Pubmed, doi:10.1016/0014-2999(86)90288-8.
Greene WM, Wang A, Nadler JV. Sodium-independent binding of L-[3H]proline to hippocampal synaptic membranes. Eur J Pharmacol. 1986 Nov 4;130(3):333–336.
Journal cover image

Published In

Eur J Pharmacol

DOI

ISSN

0014-2999

Publication Date

November 4, 1986

Volume

130

Issue

3

Start / End Page

333 / 336

Location

Netherlands

Related Subject Headings

  • Synaptic Membranes
  • Sodium
  • Rats, Inbred Strains
  • Rats
  • Proline
  • Pharmacology & Pharmacy
  • Kinetics
  • In Vitro Techniques
  • Hippocampus
  • Female