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Perforant path lesion depletes glutamate content of fascia dentata synaptosomes.

Publication ,  Journal Article
Nadler, JV; Smith, EM
Published in: Neurosci Lett
September 25, 1981

Destruction of the hippocampal perforant path fibers reduces the glutamate content of a crude synaptosomal fraction of the rat fascia dentata by about 40%, but does not reduce the aspartate content. This result supports the hypothesis that the perforant path fibers use glutamate as their transmitter. Since a perforant path lesion reduces the glutamate content of dentate homogenates to a much lesser degree, the reduction in synaptosomal glutamate may be offset by an increase in extraterminal glutamate stores. Thus, when evaluating the possible transmitter role of glutamate or aspartate, one can probably gain more definitive information by measuring the glutamate and aspartate content of a synaptosomal preparation than of the target region as a whole.

Duke Scholars

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

September 25, 1981

Volume

25

Issue

3

Start / End Page

275 / 280

Location

Ireland

Related Subject Headings

  • Synaptosomes
  • Synaptic Transmission
  • Rats, Inbred Strains
  • Rats
  • Male
  • Hippocampus
  • Glutamic Acid
  • Glutamates
  • Aspartic Acid
  • Animals
 

Citation

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Nadler, J. V., & Smith, E. M. (1981). Perforant path lesion depletes glutamate content of fascia dentata synaptosomes. Neurosci Lett, 25(3), 275–280. https://doi.org/10.1016/0304-3940(81)90404-3
Nadler, J. V., and E. M. Smith. “Perforant path lesion depletes glutamate content of fascia dentata synaptosomes.Neurosci Lett 25, no. 3 (September 25, 1981): 275–80. https://doi.org/10.1016/0304-3940(81)90404-3.
Nadler JV, Smith EM. Perforant path lesion depletes glutamate content of fascia dentata synaptosomes. Neurosci Lett. 1981 Sep 25;25(3):275–80.
Nadler, J. V., and E. M. Smith. “Perforant path lesion depletes glutamate content of fascia dentata synaptosomes.Neurosci Lett, vol. 25, no. 3, Sept. 1981, pp. 275–80. Pubmed, doi:10.1016/0304-3940(81)90404-3.
Nadler JV, Smith EM. Perforant path lesion depletes glutamate content of fascia dentata synaptosomes. Neurosci Lett. 1981 Sep 25;25(3):275–280.
Journal cover image

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

September 25, 1981

Volume

25

Issue

3

Start / End Page

275 / 280

Location

Ireland

Related Subject Headings

  • Synaptosomes
  • Synaptic Transmission
  • Rats, Inbred Strains
  • Rats
  • Male
  • Hippocampus
  • Glutamic Acid
  • Glutamates
  • Aspartic Acid
  • Animals