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Comparison of seizures and brain lesions produced by intracerebroventricular kainic acid and bicuculline methiodide.

Publication ,  Journal Article
Gruenthal, M; Armstrong, DR; Ault, B; Nadler, JV
Published in: Exp Neurol
September 1986

Intracerebroventricular kainic acid produces in rats brain lesions similar to Ammon's horn sclerosis in humans. To test the hypothesis that these lesions result indirectly from prolonged seizure activity and not from a direct action of kainic acid on the neurons that are destroyed, the effects of intracerebroventricular kainic acid and bicuculline methiodide were compared. Although bicuculline methiodide seizures differed dramatically from kainic acid seizures, both electrographically and behaviorally, the resulting brain lesions were similar for a given total limbic seizure duration. These results, in combination with other data, support the view that lesions made by intracerebroventricular administration of convulsants are indeed caused by prolonged limbic seizures. The total duration of seizure activity appears to be one important variable.

Duke Scholars

Published In

Exp Neurol

DOI

ISSN

0014-4886

Publication Date

September 1986

Volume

93

Issue

3

Start / End Page

621 / 630

Location

United States

Related Subject Headings

  • Seizures
  • Rats, Inbred Strains
  • Rats
  • Neurology & Neurosurgery
  • Male
  • Kainic Acid
  • Injections, Intraventricular
  • Hippocampus
  • Brain Diseases
  • Bicuculline
 

Citation

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Gruenthal, M., Armstrong, D. R., Ault, B., & Nadler, J. V. (1986). Comparison of seizures and brain lesions produced by intracerebroventricular kainic acid and bicuculline methiodide. Exp Neurol, 93(3), 621–630. https://doi.org/10.1016/0014-4886(86)90181-0
Gruenthal, M., D. R. Armstrong, B. Ault, and J. V. Nadler. “Comparison of seizures and brain lesions produced by intracerebroventricular kainic acid and bicuculline methiodide.Exp Neurol 93, no. 3 (September 1986): 621–30. https://doi.org/10.1016/0014-4886(86)90181-0.
Gruenthal M, Armstrong DR, Ault B, Nadler JV. Comparison of seizures and brain lesions produced by intracerebroventricular kainic acid and bicuculline methiodide. Exp Neurol. 1986 Sep;93(3):621–30.
Gruenthal, M., et al. “Comparison of seizures and brain lesions produced by intracerebroventricular kainic acid and bicuculline methiodide.Exp Neurol, vol. 93, no. 3, Sept. 1986, pp. 621–30. Pubmed, doi:10.1016/0014-4886(86)90181-0.
Gruenthal M, Armstrong DR, Ault B, Nadler JV. Comparison of seizures and brain lesions produced by intracerebroventricular kainic acid and bicuculline methiodide. Exp Neurol. 1986 Sep;93(3):621–630.
Journal cover image

Published In

Exp Neurol

DOI

ISSN

0014-4886

Publication Date

September 1986

Volume

93

Issue

3

Start / End Page

621 / 630

Location

United States

Related Subject Headings

  • Seizures
  • Rats, Inbred Strains
  • Rats
  • Neurology & Neurosurgery
  • Male
  • Kainic Acid
  • Injections, Intraventricular
  • Hippocampus
  • Brain Diseases
  • Bicuculline