Comparison of seizures and brain lesions produced by intracerebroventricular kainic acid and bicuculline methiodide.
Intracerebroventricular kainic acid produces in rats brain lesions similar to Ammon's horn sclerosis in humans. To test the hypothesis that these lesions result indirectly from prolonged seizure activity and not from a direct action of kainic acid on the neurons that are destroyed, the effects of intracerebroventricular kainic acid and bicuculline methiodide were compared. Although bicuculline methiodide seizures differed dramatically from kainic acid seizures, both electrographically and behaviorally, the resulting brain lesions were similar for a given total limbic seizure duration. These results, in combination with other data, support the view that lesions made by intracerebroventricular administration of convulsants are indeed caused by prolonged limbic seizures. The total duration of seizure activity appears to be one important variable.
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- Seizures
- Rats, Inbred Strains
- Rats
- Neurology & Neurosurgery
- Male
- Kainic Acid
- Injections, Intraventricular
- Hippocampus
- Brain Diseases
- Bicuculline
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Seizures
- Rats, Inbred Strains
- Rats
- Neurology & Neurosurgery
- Male
- Kainic Acid
- Injections, Intraventricular
- Hippocampus
- Brain Diseases
- Bicuculline