Toxicity of L-proline toward rat hippocampal neurons.
Publication
, Journal Article
Nadler, JV; Wang, A; Hakim, A
Published in: Brain Res
July 19, 1988
Intrahippocampal injections of L-proline, a neutral amino acid excitant, non-selectively destroyed pyramidal and granule cells. Co-administration of equimolar kynurenate, an excitatory amino acid antagonist, markedly reduced the extent of neuronal cell death. L-Proline destroyed far more hippocampal neurons than D-proline, in keeping with its greater neuroexcitatory potency. L-Proline must therefore be added to the list of excitotoxins present in brain. Its excitotoxic action may be related to the neurological and cognitive deficits associated with hyperprolinemia.
Duke Scholars
Published In
Brain Res
DOI
ISSN
0006-8993
Publication Date
July 19, 1988
Volume
456
Issue
1
Start / End Page
168 / 172
Location
Netherlands
Related Subject Headings
- Rats, Inbred Strains
- Rats
- Proline
- Neurotoxins
- Neurology & Neurosurgery
- Microinjections
- Male
- Hippocampus
- Dose-Response Relationship, Drug
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
Nadler, J. V., Wang, A., & Hakim, A. (1988). Toxicity of L-proline toward rat hippocampal neurons. Brain Res, 456(1), 168–172. https://doi.org/10.1016/0006-8993(88)90358-7
Nadler, J. V., A. Wang, and A. Hakim. “Toxicity of L-proline toward rat hippocampal neurons.” Brain Res 456, no. 1 (July 19, 1988): 168–72. https://doi.org/10.1016/0006-8993(88)90358-7.
Nadler JV, Wang A, Hakim A. Toxicity of L-proline toward rat hippocampal neurons. Brain Res. 1988 Jul 19;456(1):168–72.
Nadler, J. V., et al. “Toxicity of L-proline toward rat hippocampal neurons.” Brain Res, vol. 456, no. 1, July 1988, pp. 168–72. Pubmed, doi:10.1016/0006-8993(88)90358-7.
Nadler JV, Wang A, Hakim A. Toxicity of L-proline toward rat hippocampal neurons. Brain Res. 1988 Jul 19;456(1):168–172.
Published In
Brain Res
DOI
ISSN
0006-8993
Publication Date
July 19, 1988
Volume
456
Issue
1
Start / End Page
168 / 172
Location
Netherlands
Related Subject Headings
- Rats, Inbred Strains
- Rats
- Proline
- Neurotoxins
- Neurology & Neurosurgery
- Microinjections
- Male
- Hippocampus
- Dose-Response Relationship, Drug
- Animals