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Kindling, prenatal exposure to ethanol and postnatal development selectively alter responses of hippocampal pyramidal cells to NMDA.

Publication ,  Journal Article
Nadler, JV; Martin, D; Bowe, MA; Morrisett, RA; McNamara, JO
Published in: Adv Exp Med Biol
1990

Our studies suggest that treatments, such as kindling and exposure to ethanol in utero, which produce irreversible pathological changes in brain function also selectively alter neuronal responses to NMDA. We have identified increases in agonist potency, which may result from enhanced NMDA receptor expression, as well as both positive and negative modifications of Mg2+ regulation. There is no proof as yet that NMDA receptor plasticity accounts for the kindling phenomenon, for the cognitive deficits associated with fetal exposure to ethanol or for developmental events. However, all the effects we obtained are in the appropriate direction. The same functional parameters altered by kindling and prenatal exposure to ethanol are also modified during the normal development of the brain. It is tempting to speculate that these pathological stimuli produce their effects through the same mechanisms that would normally be activated by developmental signals.

Duke Scholars

Published In

Adv Exp Med Biol

DOI

ISSN

0065-2598

Publication Date

1990

Volume

268

Start / End Page

407 / 417

Location

United States

Related Subject Headings

  • Receptors, N-Methyl-D-Aspartate
  • Rats
  • Pregnancy
  • N-Methylaspartate
  • Maternal-Fetal Exchange
  • Learning
  • Kindling, Neurologic
  • Humans
  • Hippocampus
  • General & Internal Medicine
 

Citation

APA
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ICMJE
MLA
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Nadler, J. V., Martin, D., Bowe, M. A., Morrisett, R. A., & McNamara, J. O. (1990). Kindling, prenatal exposure to ethanol and postnatal development selectively alter responses of hippocampal pyramidal cells to NMDA. Adv Exp Med Biol, 268, 407–417. https://doi.org/10.1007/978-1-4684-5769-8_45
Nadler, J. V., D. Martin, M. A. Bowe, R. A. Morrisett, and J. O. McNamara. “Kindling, prenatal exposure to ethanol and postnatal development selectively alter responses of hippocampal pyramidal cells to NMDA.Adv Exp Med Biol 268 (1990): 407–17. https://doi.org/10.1007/978-1-4684-5769-8_45.
Nadler JV, Martin D, Bowe MA, Morrisett RA, McNamara JO. Kindling, prenatal exposure to ethanol and postnatal development selectively alter responses of hippocampal pyramidal cells to NMDA. Adv Exp Med Biol. 1990;268:407–17.
Nadler, J. V., et al. “Kindling, prenatal exposure to ethanol and postnatal development selectively alter responses of hippocampal pyramidal cells to NMDA.Adv Exp Med Biol, vol. 268, 1990, pp. 407–17. Pubmed, doi:10.1007/978-1-4684-5769-8_45.
Nadler JV, Martin D, Bowe MA, Morrisett RA, McNamara JO. Kindling, prenatal exposure to ethanol and postnatal development selectively alter responses of hippocampal pyramidal cells to NMDA. Adv Exp Med Biol. 1990;268:407–417.

Published In

Adv Exp Med Biol

DOI

ISSN

0065-2598

Publication Date

1990

Volume

268

Start / End Page

407 / 417

Location

United States

Related Subject Headings

  • Receptors, N-Methyl-D-Aspartate
  • Rats
  • Pregnancy
  • N-Methylaspartate
  • Maternal-Fetal Exchange
  • Learning
  • Kindling, Neurologic
  • Humans
  • Hippocampus
  • General & Internal Medicine