Skip to main content
Journal cover image

Kainic acid inhibits cholecystokinin release from rat hippocampal slices.

Publication ,  Journal Article
Bray, S; Bustos, GA; Lee, PH; Hong, JS; Aitken, PG; Nadler, JV
Published in: Neurosci Lett
May 22, 1989

Antagonistic interactions between cholecystokinin (CCK) and nanomolar concentrations of kainic acid (KA) have been reported in area CA3 of the rat hippocampal slice. This study tested the possibility that kainic acid inhibits the release of CCK. Elevated K+ was found to release CCK from hippocampal slices in a Ca2+-dependent manner. KA, at concentrations as low as 100 nM, inhibited this release by about one-third. Because CCK appears to exert a net inhibitory effect on the firing of CA3 pyramidal cells, the epileptogenic action of KA may be explained, in part, by the depression of CCK release.

Duke Scholars

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

May 22, 1989

Volume

100

Issue

1-3

Start / End Page

313 / 318

Location

Ireland

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Potassium
  • Kainic Acid
  • In Vitro Techniques
  • Hippocampus
  • Female
  • Cholecystokinin
  • Animals
  • 5202 Biological psychology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bray, S., Bustos, G. A., Lee, P. H., Hong, J. S., Aitken, P. G., & Nadler, J. V. (1989). Kainic acid inhibits cholecystokinin release from rat hippocampal slices. Neurosci Lett, 100(1–3), 313–318. https://doi.org/10.1016/0304-3940(89)90705-2
Bray, S., G. A. Bustos, P. H. Lee, J. S. Hong, P. G. Aitken, and J. V. Nadler. “Kainic acid inhibits cholecystokinin release from rat hippocampal slices.Neurosci Lett 100, no. 1–3 (May 22, 1989): 313–18. https://doi.org/10.1016/0304-3940(89)90705-2.
Bray S, Bustos GA, Lee PH, Hong JS, Aitken PG, Nadler JV. Kainic acid inhibits cholecystokinin release from rat hippocampal slices. Neurosci Lett. 1989 May 22;100(1–3):313–8.
Bray, S., et al. “Kainic acid inhibits cholecystokinin release from rat hippocampal slices.Neurosci Lett, vol. 100, no. 1–3, May 1989, pp. 313–18. Pubmed, doi:10.1016/0304-3940(89)90705-2.
Bray S, Bustos GA, Lee PH, Hong JS, Aitken PG, Nadler JV. Kainic acid inhibits cholecystokinin release from rat hippocampal slices. Neurosci Lett. 1989 May 22;100(1–3):313–318.
Journal cover image

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

May 22, 1989

Volume

100

Issue

1-3

Start / End Page

313 / 318

Location

Ireland

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Potassium
  • Kainic Acid
  • In Vitro Techniques
  • Hippocampus
  • Female
  • Cholecystokinin
  • Animals
  • 5202 Biological psychology