Desensitization-like changes in GABA receptor binding of rat fascia dentata after entorhinal lesion.
Publication
, Journal Article
Nadler, JV
Published in: Neurosci Lett
November 4, 1981
Destruction of the hippocampal perforant path fibers reduced the binding of [3H]GABA to membranes prepared from the rat fascia dentata. This result could be detected 1--4 months after surgery, but not in 10 days or less. Such a delayed response appears most compatible with a transsynaptic effect on GABA receptors. Values of low affinity KD and Bmax decreased by about 65%, but no changes were detected in high affinity binding, Hill slope or pharmacological specificity. These findings are consistent with a desensitization of postsynaptic low affinity GABA receptors, possible caused by excessive release of GABA.
Duke Scholars
Published In
Neurosci Lett
DOI
ISSN
0304-3940
Publication Date
November 4, 1981
Volume
26
Issue
3
Start / End Page
275 / 281
Location
Ireland
Related Subject Headings
- gamma-Aminobutyric Acid
- Synaptic Transmission
- Synapses
- Smell
- Sensory Deprivation
- Receptors, Drug
- Rats, Inbred Strains
- Rats
- Nose
- Male
Citation
APA
Chicago
ICMJE
MLA
NLM
Nadler, J. V. (1981). Desensitization-like changes in GABA receptor binding of rat fascia dentata after entorhinal lesion. Neurosci Lett, 26(3), 275–281. https://doi.org/10.1016/0304-3940(81)90145-2
Nadler, J. V. “Desensitization-like changes in GABA receptor binding of rat fascia dentata after entorhinal lesion.” Neurosci Lett 26, no. 3 (November 4, 1981): 275–81. https://doi.org/10.1016/0304-3940(81)90145-2.
Nadler JV. Desensitization-like changes in GABA receptor binding of rat fascia dentata after entorhinal lesion. Neurosci Lett. 1981 Nov 4;26(3):275–81.
Nadler, J. V. “Desensitization-like changes in GABA receptor binding of rat fascia dentata after entorhinal lesion.” Neurosci Lett, vol. 26, no. 3, Nov. 1981, pp. 275–81. Pubmed, doi:10.1016/0304-3940(81)90145-2.
Nadler JV. Desensitization-like changes in GABA receptor binding of rat fascia dentata after entorhinal lesion. Neurosci Lett. 1981 Nov 4;26(3):275–281.
Published In
Neurosci Lett
DOI
ISSN
0304-3940
Publication Date
November 4, 1981
Volume
26
Issue
3
Start / End Page
275 / 281
Location
Ireland
Related Subject Headings
- gamma-Aminobutyric Acid
- Synaptic Transmission
- Synapses
- Smell
- Sensory Deprivation
- Receptors, Drug
- Rats, Inbred Strains
- Rats
- Nose
- Male