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Neuropeptide Y in the recurrent mossy fiber pathway.

Publication ,  Journal Article
Nadler, JV; Tu, B; Timofeeva, O; Jiao, Y; Herzog, H
Published in: Peptides
February 2007

In the epileptic brain, hippocampal dentate granule cells become synaptically interconnected through the sprouting of mossy fibers. This new circuitry is expected to facilitate epileptiform discharge. Prolonged seizures induce the long-lasting neoexpression of neuropeptide Y (NPY) in mossy fibers. NPY is released spontaneously from recurrent mossy fiber terminals, reduces glutamate release from those terminals by activating presynaptic Y2 receptors, and depresses granule cell epileptiform activity dependent on the recurrent pathway. These effects are much greater in rats than in C57BL/6 mice, despite apparently equivalent mossy fiber sprouting and neoexpression of NPY. This species difference can be explained by contrasting changes in the expression of mossy fiber Y2 receptors; seizures upregulate Y2 receptors in rats but downregulate them in mice. The recurrent mossy fiber pathway may synchronize granule cell discharge more effectively in humans and mice than in rats, due to its lower expression of either NPY (humans) or Y2 receptors (mice).

Duke Scholars

Published In

Peptides

DOI

ISSN

0196-9781

Publication Date

February 2007

Volume

28

Issue

2

Start / End Page

357 / 364

Location

United States

Related Subject Headings

  • Synaptic Transmission
  • Status Epilepticus
  • Species Specificity
  • Receptors, Neuropeptide Y
  • Rats
  • Pilocarpine
  • Neuropeptide Y
  • Neuronal Plasticity
  • Mossy Fibers, Hippocampal
  • Mice
 

Citation

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Nadler, J. V., Tu, B., Timofeeva, O., Jiao, Y., & Herzog, H. (2007). Neuropeptide Y in the recurrent mossy fiber pathway. Peptides, 28(2), 357–364. https://doi.org/10.1016/j.peptides.2006.07.026
Nadler, J Victor, Bin Tu, Olga Timofeeva, Yiqun Jiao, and Herbert Herzog. “Neuropeptide Y in the recurrent mossy fiber pathway.Peptides 28, no. 2 (February 2007): 357–64. https://doi.org/10.1016/j.peptides.2006.07.026.
Nadler JV, Tu B, Timofeeva O, Jiao Y, Herzog H. Neuropeptide Y in the recurrent mossy fiber pathway. Peptides. 2007 Feb;28(2):357–64.
Nadler, J. Victor, et al. “Neuropeptide Y in the recurrent mossy fiber pathway.Peptides, vol. 28, no. 2, Feb. 2007, pp. 357–64. Pubmed, doi:10.1016/j.peptides.2006.07.026.
Nadler JV, Tu B, Timofeeva O, Jiao Y, Herzog H. Neuropeptide Y in the recurrent mossy fiber pathway. Peptides. 2007 Feb;28(2):357–364.
Journal cover image

Published In

Peptides

DOI

ISSN

0196-9781

Publication Date

February 2007

Volume

28

Issue

2

Start / End Page

357 / 364

Location

United States

Related Subject Headings

  • Synaptic Transmission
  • Status Epilepticus
  • Species Specificity
  • Receptors, Neuropeptide Y
  • Rats
  • Pilocarpine
  • Neuropeptide Y
  • Neuronal Plasticity
  • Mossy Fibers, Hippocampal
  • Mice