Skip to main content

Rb and p16INK4a expression in resected non-small cell lung tumors.

Publication ,  Journal Article
Kratzke, RA; Greatens, TM; Rubins, JB; Maddaus, MA; Niewoehner, DE; Niehans, GA; Geradts, J
Published in: Cancer Res
August 1, 1996

Inactivation of the cyclin-dependent kinase inhibitor p16INK4a (CDKN2/MTS1) is documented in a wide variety of cancer cell lines and tumors. We have shown that loss of p16INK4a protein expression is a common event in early stage non-small cell lung cancer (NSCLC), correlates with a significantly worse survival, and is more common in higher stage disease. One hundred NSCLC tumors from patients undergoing definitive thoracotomies at a single institution were examined for p16INK4a and retinoblastoma protein (pRB) expression. Abnormal pRB staining was identified in 15% of the tumors, whereas 51% possessed aberrant p16INK4a protein expression. Tumors with aberrant expression of p16INK4a by immunohistochemistry were associated with a significantly worse survival (P=0.04). Additionally, the inverse correlation of pRB and p16INK4a expression previously noted in lung cancer cell lines and tumors was confirmed in this large cohort of patients, with 65% of the tumors demonstrating inverse expression of pRB and p16INK4a (p=0.00019). A statistically significant increase in aberrant p16INK4a expression, as well as inverse expression of p16INK4a and pRB, was seen with increasing pathological stage of disease. These findings establish the prognostic significance (of the absence of p16INK4, in resected NSCLC and confirm the critical importance of disrupting the pathway of cyclin-dependent kinase-mediated phosphorylation of pRB in the molecular oncogenesis and progression of NSCLC.

Duke Scholars

Published In

Cancer Res

ISSN

0008-5472

Publication Date

August 1, 1996

Volume

56

Issue

15

Start / End Page

3415 / 3420

Location

United States

Related Subject Headings

  • Retinoblastoma Protein
  • Prognosis
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Middle Aged
  • Lung Neoplasms
  • Humans
  • Gene Expression
  • Cyclin-Dependent Kinase Inhibitor p16
  • Carrier Proteins
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kratzke, R. A., Greatens, T. M., Rubins, J. B., Maddaus, M. A., Niewoehner, D. E., Niehans, G. A., & Geradts, J. (1996). Rb and p16INK4a expression in resected non-small cell lung tumors. Cancer Res, 56(15), 3415–3420.
Kratzke, R. A., T. M. Greatens, J. B. Rubins, M. A. Maddaus, D. E. Niewoehner, G. A. Niehans, and J. Geradts. “Rb and p16INK4a expression in resected non-small cell lung tumors.Cancer Res 56, no. 15 (August 1, 1996): 3415–20.
Kratzke RA, Greatens TM, Rubins JB, Maddaus MA, Niewoehner DE, Niehans GA, et al. Rb and p16INK4a expression in resected non-small cell lung tumors. Cancer Res. 1996 Aug 1;56(15):3415–20.
Kratzke, R. A., et al. “Rb and p16INK4a expression in resected non-small cell lung tumors.Cancer Res, vol. 56, no. 15, Aug. 1996, pp. 3415–20.
Kratzke RA, Greatens TM, Rubins JB, Maddaus MA, Niewoehner DE, Niehans GA, Geradts J. Rb and p16INK4a expression in resected non-small cell lung tumors. Cancer Res. 1996 Aug 1;56(15):3415–3420.

Published In

Cancer Res

ISSN

0008-5472

Publication Date

August 1, 1996

Volume

56

Issue

15

Start / End Page

3415 / 3420

Location

United States

Related Subject Headings

  • Retinoblastoma Protein
  • Prognosis
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Middle Aged
  • Lung Neoplasms
  • Humans
  • Gene Expression
  • Cyclin-Dependent Kinase Inhibitor p16
  • Carrier Proteins