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Mammographic predictors of the presence and size of invasive carcinomas associated with malignant microcalcification lesions without a mass.

Publication ,  Journal Article
Stomper, PC; Geradts, J; Edge, SB; Levine, EG
Published in: AJR Am J Roentgenol
December 2003

OBJECTIVE: Our objective was to determine the degree with which mammographic features predict the presence and size of invasive carcinomas associated with malignant mammographic microcalcification lesions without a mass. MATERIALS AND METHODS: Mammographic features were correlated with pathologic features in 304 consecutive breast carcinomas manifested by mammographic calcifications only in a prospective evaluation. RESULTS: Mammographic calcifications associated with breast carcinoma had the final pathologic diagnoses of pure ductal carcinoma in situ (DCIS) in 65% of patients, DCIS with a focus of invasion in 32%, and invasive carcinoma only in 4%. Invasive foci were more likely associated with mammographic calcification size of 11 mm and greater (40%, 77/194) compared with 1-10 mm (26%, 29/110; p = 0.019). Invasive foci were also more likely associated with linear calcifications (44%, 55/126) compared with granular calcifications (29%, 51/178; p = 0.007). The frequency of invasion did not increase with calcification extents greater than 10 mm. The frequency of invasion ranged from 22% for less than or equal to 5-mm granular calcifications to 45% for linear calcifications of 11 mm and greater. Only 11% of cancers characterized by fine granular calcifications were associated with invasion as compared with 32% of those with coarse and mixed granular calcifications (p = 0.002). CONCLUSION: Mammographic calcification features of malignant lesions cannot predict the absence of invasion with greater than 90% predictive value or predict the presence of invasion with greater than 45% predictive value. Increased extent of calcifications greater than 10 mm was not associated with greater likelihood of invasion.

Duke Scholars

Published In

AJR Am J Roentgenol

DOI

ISSN

0361-803X

Publication Date

December 2003

Volume

181

Issue

6

Start / End Page

1679 / 1684

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Prospective Studies
  • Predictive Value of Tests
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Mammography
  • Humans
  • Female
  • Carcinoma, Intraductal, Noninfiltrating
  • Carcinoma, Ductal, Breast
 

Citation

APA
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MLA
NLM
Stomper, P. C., Geradts, J., Edge, S. B., & Levine, E. G. (2003). Mammographic predictors of the presence and size of invasive carcinomas associated with malignant microcalcification lesions without a mass. AJR Am J Roentgenol, 181(6), 1679–1684. https://doi.org/10.2214/ajr.181.6.1811679
Stomper, Paul C., Joseph Geradts, Stephen B. Edge, and Ellis G. Levine. “Mammographic predictors of the presence and size of invasive carcinomas associated with malignant microcalcification lesions without a mass.AJR Am J Roentgenol 181, no. 6 (December 2003): 1679–84. https://doi.org/10.2214/ajr.181.6.1811679.
Stomper, Paul C., et al. “Mammographic predictors of the presence and size of invasive carcinomas associated with malignant microcalcification lesions without a mass.AJR Am J Roentgenol, vol. 181, no. 6, Dec. 2003, pp. 1679–84. Pubmed, doi:10.2214/ajr.181.6.1811679.

Published In

AJR Am J Roentgenol

DOI

ISSN

0361-803X

Publication Date

December 2003

Volume

181

Issue

6

Start / End Page

1679 / 1684

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Prospective Studies
  • Predictive Value of Tests
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Mammography
  • Humans
  • Female
  • Carcinoma, Intraductal, Noninfiltrating
  • Carcinoma, Ductal, Breast