Combination chemotherapy in histiocytosis X.
Publication
, Journal Article
Komp, DM; Vietti, TJ; Berry, DH; Starling, KA; Haggard, ME; George, SL
Published in: Med Pediatr Oncol
1977
Twenty-five children with generalized histiocytosis X were treated with a combination of cyclophosphamide, vinblastine, and prednisone: 8 patients experienced complete response, 8 partial response, 2 imporvement, and 7 no response. Response rates for children over 1 year of age were higher than those reported for single agents. Twelve children are now off therapy with no evidence of disease for 10--50 months. Very poor response rates and high toxicity were seen in children less than 1 year of age. The two infants who eventually achieved CR did so by other therapies. Further trials in combination chemotherapy must weight possible long-term effects of such therapy against the prospect of more rapid disease control.
Duke Scholars
Published In
Med Pediatr Oncol
DOI
ISSN
0098-1532
Publication Date
1977
Volume
3
Issue
3
Start / End Page
267 / 273
Location
United States
Related Subject Headings
- Vinblastine
- Time Factors
- Prednisone
- Oncology & Carcinogenesis
- Injections, Intravenous
- Infant
- Humans
- Histiocytosis, Langerhans-Cell
- Drug Therapy, Combination
- Drug Evaluation
Citation
APA
Chicago
ICMJE
MLA
NLM
Komp, D. M., Vietti, T. J., Berry, D. H., Starling, K. A., Haggard, M. E., & George, S. L. (1977). Combination chemotherapy in histiocytosis X. Med Pediatr Oncol, 3(3), 267–273. https://doi.org/10.1002/mpo.2950030308
Komp, D. M., T. J. Vietti, D. H. Berry, K. A. Starling, M. E. Haggard, and S. L. George. “Combination chemotherapy in histiocytosis X.” Med Pediatr Oncol 3, no. 3 (1977): 267–73. https://doi.org/10.1002/mpo.2950030308.
Komp DM, Vietti TJ, Berry DH, Starling KA, Haggard ME, George SL. Combination chemotherapy in histiocytosis X. Med Pediatr Oncol. 1977;3(3):267–73.
Komp, D. M., et al. “Combination chemotherapy in histiocytosis X.” Med Pediatr Oncol, vol. 3, no. 3, 1977, pp. 267–73. Pubmed, doi:10.1002/mpo.2950030308.
Komp DM, Vietti TJ, Berry DH, Starling KA, Haggard ME, George SL. Combination chemotherapy in histiocytosis X. Med Pediatr Oncol. 1977;3(3):267–273.
Published In
Med Pediatr Oncol
DOI
ISSN
0098-1532
Publication Date
1977
Volume
3
Issue
3
Start / End Page
267 / 273
Location
United States
Related Subject Headings
- Vinblastine
- Time Factors
- Prednisone
- Oncology & Carcinogenesis
- Injections, Intravenous
- Infant
- Humans
- Histiocytosis, Langerhans-Cell
- Drug Therapy, Combination
- Drug Evaluation