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Effects of CKS-17, a synthetic retroviral envelope peptide, on cell-mediated immunity in vivo: immunosuppression, immunogenicity, and relation to immunosuppressive tumor products.

Publication ,  Journal Article
Nelson, M; Nelson, DS; Cianciolo, GJ; Snyderman, R
Published in: Cancer Immunol Immunother
1989

CKS-17 is a heptadecapeptide corresponding to a region highly conserved in retroviral transmembrane proteins such as p15E. Because a relationship had previously been determined between p15E and immunosuppressive tumor cell products, we examined the effect of CKS-17, control peptides and conjugates thereof on the expression of cell-mediated immunity (delayed-type hypersensitivity, DTH) in mice. Conjugates of CKS-17 inhibited DTH reactions to sheep erythrocytes in the feet of mice. The degree of inhibition was dose-dependent. Unconjugated CKS-17 had almost no effect, and control peptide conjugates had no inhibitory effect. Immunization of mice with CKS-17 conjugates, but not with control conjugates, rendered them resistant to the depression of DTH reactions, not only by CKS-17 conjugates, but also by products of cultured tumor cells. CKS-17 conjugates, but not control conjugates, also depressed the cellular inflammatory reactions induced in mouse footpads by concanavalin A (ConA) and immunized mice against the depression of ConA reactions by products of cultured tumor cells. Injections of globulin from sera of mice immunized with CKS-17 conjugates conferred upon normal recipients resistance to the depression of footpad reactions to ConA by products of cultured tumor cells. Globulin from sera of normal mice or control immunized mice did not confer such resistance. Thus conjugates of a synthetic peptide not only mimic the immunosuppressive effects of tumor products in vivo, but can also immunize mice against those effects.

Duke Scholars

Published In

Cancer Immunol Immunother

DOI

ISSN

0340-7004

Publication Date

1989

Volume

30

Issue

2

Start / End Page

113 / 118

Location

Germany

Related Subject Headings

  • Retroviridae Proteins, Oncogenic
  • Peptides
  • Neoplasms, Experimental
  • Mice, Inbred C57BL
  • Mice
  • Intercellular Signaling Peptides and Proteins
  • Immunosuppressive Agents
  • Immunology
  • Immunization
  • Immunity, Cellular
 

Citation

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Nelson, M., Nelson, D. S., Cianciolo, G. J., & Snyderman, R. (1989). Effects of CKS-17, a synthetic retroviral envelope peptide, on cell-mediated immunity in vivo: immunosuppression, immunogenicity, and relation to immunosuppressive tumor products. Cancer Immunol Immunother, 30(2), 113–118. https://doi.org/10.1007/BF01665962
Nelson, M., D. S. Nelson, G. J. Cianciolo, and R. Snyderman. “Effects of CKS-17, a synthetic retroviral envelope peptide, on cell-mediated immunity in vivo: immunosuppression, immunogenicity, and relation to immunosuppressive tumor products.Cancer Immunol Immunother 30, no. 2 (1989): 113–18. https://doi.org/10.1007/BF01665962.
Nelson, M., et al. “Effects of CKS-17, a synthetic retroviral envelope peptide, on cell-mediated immunity in vivo: immunosuppression, immunogenicity, and relation to immunosuppressive tumor products.Cancer Immunol Immunother, vol. 30, no. 2, 1989, pp. 113–18. Pubmed, doi:10.1007/BF01665962.
Journal cover image

Published In

Cancer Immunol Immunother

DOI

ISSN

0340-7004

Publication Date

1989

Volume

30

Issue

2

Start / End Page

113 / 118

Location

Germany

Related Subject Headings

  • Retroviridae Proteins, Oncogenic
  • Peptides
  • Neoplasms, Experimental
  • Mice, Inbred C57BL
  • Mice
  • Intercellular Signaling Peptides and Proteins
  • Immunosuppressive Agents
  • Immunology
  • Immunization
  • Immunity, Cellular