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Comparison of the effects of hydralazine on tumor and normal tissue blood perfusion by MRI.

Publication ,  Journal Article
Belfi, CA; Paul, CR; Shan, S; Ngo, FQ
Published in: Int J Radiat Oncol Biol Phys
June 15, 1994

PURPOSE: The differential effects on blood perfusion of the vasodilator hydralazine (HYD) between tumor and normal muscle have been measured using the dynamic enhanced-magnetic resonance imaging (DE-MRI) technique. METHODS AND MATERIALS: DE-MRI is a noninvasive method of determining blood perfusion in tumors and normal tissues using the MR contrast agent Gd-DTPA. Hydralazine is currently being used in an attempt to increase tumor response to bioreductive agents and to hyperthermia. RESULTS: We show that a dose of 1.2 mg/kg HYD causes an increase in tumor perfusion while doses > or = 2.5 mg/kg cause a decrease in tumor perfusion. The latter was accompanied by a dose-dependent increase in normal muscle perfusion consistent with the "steal effect." CONCLUSION: This study demonstrates the sensitivity of the DE-MRI technique and its capability of providing estimates of blood perfusion in normal and tumor tissue as well as in smaller regions of a solid tumor. Such features would make it clinically useful in the study of tumor response to radiation therapy and chemotherapy in patients.

Duke Scholars

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

June 15, 1994

Volume

29

Issue

3

Start / End Page

473 / 479

Location

United States

Related Subject Headings

  • Sarcoma, Experimental
  • Regional Blood Flow
  • Pentetic Acid
  • Organometallic Compounds
  • Oncology & Carcinogenesis
  • Muscles
  • Mice, Inbred C3H
  • Mice
  • Magnetic Resonance Imaging
  • Hydralazine
 

Citation

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ICMJE
MLA
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Belfi, C. A., Paul, C. R., Shan, S., & Ngo, F. Q. (1994). Comparison of the effects of hydralazine on tumor and normal tissue blood perfusion by MRI. Int J Radiat Oncol Biol Phys, 29(3), 473–479. https://doi.org/10.1016/0360-3016(94)90441-3
Belfi, C. A., C. R. Paul, S. Shan, and F. Q. Ngo. “Comparison of the effects of hydralazine on tumor and normal tissue blood perfusion by MRI.Int J Radiat Oncol Biol Phys 29, no. 3 (June 15, 1994): 473–79. https://doi.org/10.1016/0360-3016(94)90441-3.
Belfi CA, Paul CR, Shan S, Ngo FQ. Comparison of the effects of hydralazine on tumor and normal tissue blood perfusion by MRI. Int J Radiat Oncol Biol Phys. 1994 Jun 15;29(3):473–9.
Belfi, C. A., et al. “Comparison of the effects of hydralazine on tumor and normal tissue blood perfusion by MRI.Int J Radiat Oncol Biol Phys, vol. 29, no. 3, June 1994, pp. 473–79. Pubmed, doi:10.1016/0360-3016(94)90441-3.
Belfi CA, Paul CR, Shan S, Ngo FQ. Comparison of the effects of hydralazine on tumor and normal tissue blood perfusion by MRI. Int J Radiat Oncol Biol Phys. 1994 Jun 15;29(3):473–479.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

June 15, 1994

Volume

29

Issue

3

Start / End Page

473 / 479

Location

United States

Related Subject Headings

  • Sarcoma, Experimental
  • Regional Blood Flow
  • Pentetic Acid
  • Organometallic Compounds
  • Oncology & Carcinogenesis
  • Muscles
  • Mice, Inbred C3H
  • Mice
  • Magnetic Resonance Imaging
  • Hydralazine