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Control of idiotope expression by monoclonal anti-idiotope and idiotope-bearing antibody.

Publication ,  Journal Article
Kelsoe, G; Reth, M; Rajewsky, K
Published in: Eur J Immunol
May 1981

Preinjection of C57BL/6 mice with nano-to microgram amounts of a monoclonal IgG1 antibody directed against a binding site-related idiotope of the anti-NP [(4-hydroxy-3-nitro-phenyl)acetyl] antibody B1-8 results in enhancement or suppression of the corresponding and of another B1-8 idiotope in a subsequent anti-NP response, depending on the dose of the injected anti-idiotope antibody. The enhancing and suppressive effects appear two weeks after anti-idiotope administration and are maximal after 6-8 weeks. They are predominantly expressed at the level of IgG, not IgM, antibodies. Enhancement of idiotype expression, i.e. idiotypic memory, can also be induced by the injection of idiotypic antibody of the IgM class, namely antibody B1-8. This effect might represent one of the general mechanisms by which immunological memory is established.

Duke Scholars

Published In

Eur J Immunol

DOI

ISSN

0014-2980

Publication Date

May 1981

Volume

11

Issue

5

Start / End Page

418 / 423

Location

Germany

Related Subject Headings

  • Phenylacetates
  • Nitrophenols
  • Mice, Inbred C57BL
  • Mice
  • Immunology
  • Immunoglobulin Idiotypes
  • Immunoglobulin G
  • Female
  • Dose-Response Relationship, Immunologic
  • Antibody Formation
 

Citation

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Kelsoe, G., Reth, M., & Rajewsky, K. (1981). Control of idiotope expression by monoclonal anti-idiotope and idiotope-bearing antibody. Eur J Immunol, 11(5), 418–423. https://doi.org/10.1002/eji.1830110513
Kelsoe, G., M. Reth, and K. Rajewsky. “Control of idiotope expression by monoclonal anti-idiotope and idiotope-bearing antibody.Eur J Immunol 11, no. 5 (May 1981): 418–23. https://doi.org/10.1002/eji.1830110513.
Kelsoe G, Reth M, Rajewsky K. Control of idiotope expression by monoclonal anti-idiotope and idiotope-bearing antibody. Eur J Immunol. 1981 May;11(5):418–23.
Kelsoe, G., et al. “Control of idiotope expression by monoclonal anti-idiotope and idiotope-bearing antibody.Eur J Immunol, vol. 11, no. 5, May 1981, pp. 418–23. Pubmed, doi:10.1002/eji.1830110513.
Kelsoe G, Reth M, Rajewsky K. Control of idiotope expression by monoclonal anti-idiotope and idiotope-bearing antibody. Eur J Immunol. 1981 May;11(5):418–423.
Journal cover image

Published In

Eur J Immunol

DOI

ISSN

0014-2980

Publication Date

May 1981

Volume

11

Issue

5

Start / End Page

418 / 423

Location

Germany

Related Subject Headings

  • Phenylacetates
  • Nitrophenols
  • Mice, Inbred C57BL
  • Mice
  • Immunology
  • Immunoglobulin Idiotypes
  • Immunoglobulin G
  • Female
  • Dose-Response Relationship, Immunologic
  • Antibody Formation