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Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum.

Publication ,  Journal Article
Dang, MT; Yokoi, F; Yin, HH; Lovinger, DM; Wang, Y; Li, Y
Published in: Proceedings of the National Academy of Sciences of the United States of America
October 2006

Much research has implicated the striatum in motor learning, but the underlying mechanisms have not been identified. Although NMDA receptor (NMDAR)-dependent long-term potentiation has been observed in the striatum, its involvement in motor learning remains unclear. To examine the role of striatal NMDAR in motor learning, we created striatum-specific NMDAR1 subunit knockout mice, analyzed the striatal anatomy and neuronal morphology of these mice, evaluated their performance on well established motor tasks, and performed electrophysiological recordings to assay striatal NMDAR function and long-term synaptic plasticity. Our results show that deleting the NMDAR1 subunit of the NMDAR specifically in the striatum, which virtually abolished NMDAR-mediated currents, resulted in only small changes in striatal neuronal morphology but severely impaired motor learning and disrupted dorsal striatal long-term potentiation and ventral striatal long-term depression.

Duke Scholars

Published In

Proceedings of the National Academy of Sciences of the United States of America

DOI

EISSN

1091-6490

ISSN

0027-8424

Publication Date

October 2006

Volume

103

Issue

41

Start / End Page

15254 / 15259

Related Subject Headings

  • Synapses
  • Receptors, N-Methyl-D-Aspartate
  • RGS Proteins
  • Neuronal Plasticity
  • Mice, Knockout
  • Mice
  • Long-Term Potentiation
  • Learning
  • Corpus Striatum
  • Basal Ganglia
 

Citation

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Chicago
ICMJE
MLA
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Dang, M. T., Yokoi, F., Yin, H. H., Lovinger, D. M., Wang, Y., & Li, Y. (2006). Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum. Proceedings of the National Academy of Sciences of the United States of America, 103(41), 15254–15259. https://doi.org/10.1073/pnas.0601758103
Dang, Mai T., Fumiaki Yokoi, Henry H. Yin, David M. Lovinger, Yanyan Wang, and Yuqing Li. “Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum.Proceedings of the National Academy of Sciences of the United States of America 103, no. 41 (October 2006): 15254–59. https://doi.org/10.1073/pnas.0601758103.
Dang MT, Yokoi F, Yin HH, Lovinger DM, Wang Y, Li Y. Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum. Proceedings of the National Academy of Sciences of the United States of America. 2006 Oct;103(41):15254–9.
Dang, Mai T., et al. “Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum.Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 41, Oct. 2006, pp. 15254–59. Epmc, doi:10.1073/pnas.0601758103.
Dang MT, Yokoi F, Yin HH, Lovinger DM, Wang Y, Li Y. Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum. Proceedings of the National Academy of Sciences of the United States of America. 2006 Oct;103(41):15254–15259.
Journal cover image

Published In

Proceedings of the National Academy of Sciences of the United States of America

DOI

EISSN

1091-6490

ISSN

0027-8424

Publication Date

October 2006

Volume

103

Issue

41

Start / End Page

15254 / 15259

Related Subject Headings

  • Synapses
  • Receptors, N-Methyl-D-Aspartate
  • RGS Proteins
  • Neuronal Plasticity
  • Mice, Knockout
  • Mice
  • Long-Term Potentiation
  • Learning
  • Corpus Striatum
  • Basal Ganglia