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Kainic acid lesions disrupt fear-mediated memory processing.

Publication ,  Journal Article
Yin, H; Bardgett, ME; Csernansky, JG
Published in: Neurobiology of learning and memory
May 2002

Previous research has shown that hippocampal lesions impair the expression of fear conditioning. This fear conditioning deficit may be due to memory impairment or a reduction in fear in lesioned animals. To address these possibilities, the authors examined unconditioned and conditioned fear in male Sprague-Dawley rats that had received intracerebroventricular (ICV) infusions of kainic acid (KA) 30 days prior to testing. Animals that had received bilateral ICV infusions of KA (1.0 microl of 0.8 mg/ml solution per side) exhibited cell loss that was primarily confined to the CA3 region of the dorsal hippocampus. Kainic acid lesions impaired contextual and cued fear conditioning but did not affect unconditioned fear in a light:dark test of anxiety. Moreover, animals with KA lesions did not habituate to the light:dark apparatus when tested over a 3-day period. These data suggest that decreases in fear conditioning produced by hippocampal lesions reflect a memory deficit and not a lack of fear.

Duke Scholars

Published In

Neurobiology of learning and memory

DOI

EISSN

1095-9564

ISSN

1074-7427

Publication Date

May 2002

Volume

77

Issue

3

Start / End Page

389 / 401

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Memory Disorders
  • Male
  • Light
  • Kainic Acid
  • Fear
  • Conditioning, Psychological
  • Brain
  • Behavioral Science & Comparative Psychology
 

Citation

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MLA
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Yin, H., Bardgett, M. E., & Csernansky, J. G. (2002). Kainic acid lesions disrupt fear-mediated memory processing. Neurobiology of Learning and Memory, 77(3), 389–401. https://doi.org/10.1006/nlme.2001.4037
Yin, Henry, Mark E. Bardgett, and John G. Csernansky. “Kainic acid lesions disrupt fear-mediated memory processing.Neurobiology of Learning and Memory 77, no. 3 (May 2002): 389–401. https://doi.org/10.1006/nlme.2001.4037.
Yin H, Bardgett ME, Csernansky JG. Kainic acid lesions disrupt fear-mediated memory processing. Neurobiology of learning and memory. 2002 May;77(3):389–401.
Yin, Henry, et al. “Kainic acid lesions disrupt fear-mediated memory processing.Neurobiology of Learning and Memory, vol. 77, no. 3, May 2002, pp. 389–401. Epmc, doi:10.1006/nlme.2001.4037.
Yin H, Bardgett ME, Csernansky JG. Kainic acid lesions disrupt fear-mediated memory processing. Neurobiology of learning and memory. 2002 May;77(3):389–401.
Journal cover image

Published In

Neurobiology of learning and memory

DOI

EISSN

1095-9564

ISSN

1074-7427

Publication Date

May 2002

Volume

77

Issue

3

Start / End Page

389 / 401

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Memory Disorders
  • Male
  • Light
  • Kainic Acid
  • Fear
  • Conditioning, Psychological
  • Brain
  • Behavioral Science & Comparative Psychology