Tumor-suppressor p53: implications for tumor development and prognosis.
Publication
, Journal Article
Kirsch, DG; Kastan, MB
Published in: J Clin Oncol
September 1998
The p53 protein plays a central role in modulating cellular responses to cytotoxic stresses by contributing to both cell-cycle arrest and programmed cell death. Loss of p53 function during tumorigenesis can lead to inappropriate cell growth, increased cell survival, and genetic instability. p53 gene mutations occur in approximately half of all malignancies from a wide range of human tumors. In some tumor types, these p53 mutations are associated with poor prognosis and treatment failure. Based on these insights, new approaches are being developed to prevent, diagnose, and treat cancer.
Duke Scholars
Published In
J Clin Oncol
DOI
ISSN
0732-183X
Publication Date
September 1998
Volume
16
Issue
9
Start / End Page
3158 / 3168
Location
United States
Related Subject Headings
- Tumor Suppressor Protein p53
- Prognosis
- Oncology & Carcinogenesis
- Neoplasms
- Mutation
- Humans
- Genes, p53
- Cell Cycle
- Apoptosis
- 3211 Oncology and carcinogenesis
Citation
APA
Chicago
ICMJE
MLA
NLM
Kirsch, D. G., & Kastan, M. B. (1998). Tumor-suppressor p53: implications for tumor development and prognosis. J Clin Oncol, 16(9), 3158–3168. https://doi.org/10.1200/JCO.1998.16.9.3158
Kirsch, D. G., and M. B. Kastan. “Tumor-suppressor p53: implications for tumor development and prognosis.” J Clin Oncol 16, no. 9 (September 1998): 3158–68. https://doi.org/10.1200/JCO.1998.16.9.3158.
Kirsch DG, Kastan MB. Tumor-suppressor p53: implications for tumor development and prognosis. J Clin Oncol. 1998 Sep;16(9):3158–68.
Kirsch, D. G., and M. B. Kastan. “Tumor-suppressor p53: implications for tumor development and prognosis.” J Clin Oncol, vol. 16, no. 9, Sept. 1998, pp. 3158–68. Pubmed, doi:10.1200/JCO.1998.16.9.3158.
Kirsch DG, Kastan MB. Tumor-suppressor p53: implications for tumor development and prognosis. J Clin Oncol. 1998 Sep;16(9):3158–3168.
Published In
J Clin Oncol
DOI
ISSN
0732-183X
Publication Date
September 1998
Volume
16
Issue
9
Start / End Page
3158 / 3168
Location
United States
Related Subject Headings
- Tumor Suppressor Protein p53
- Prognosis
- Oncology & Carcinogenesis
- Neoplasms
- Mutation
- Humans
- Genes, p53
- Cell Cycle
- Apoptosis
- 3211 Oncology and carcinogenesis