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Tumor-suppressor p53: implications for tumor development and prognosis.

Publication ,  Journal Article
Kirsch, DG; Kastan, MB
Published in: J Clin Oncol
September 1998

The p53 protein plays a central role in modulating cellular responses to cytotoxic stresses by contributing to both cell-cycle arrest and programmed cell death. Loss of p53 function during tumorigenesis can lead to inappropriate cell growth, increased cell survival, and genetic instability. p53 gene mutations occur in approximately half of all malignancies from a wide range of human tumors. In some tumor types, these p53 mutations are associated with poor prognosis and treatment failure. Based on these insights, new approaches are being developed to prevent, diagnose, and treat cancer.

Duke Scholars

Published In

J Clin Oncol

DOI

ISSN

0732-183X

Publication Date

September 1998

Volume

16

Issue

9

Start / End Page

3158 / 3168

Location

United States

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Prognosis
  • Oncology & Carcinogenesis
  • Neoplasms
  • Mutation
  • Humans
  • Genes, p53
  • Cell Cycle
  • Apoptosis
  • 3211 Oncology and carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kirsch, D. G., & Kastan, M. B. (1998). Tumor-suppressor p53: implications for tumor development and prognosis. J Clin Oncol, 16(9), 3158–3168. https://doi.org/10.1200/JCO.1998.16.9.3158
Kirsch, D. G., and M. B. Kastan. “Tumor-suppressor p53: implications for tumor development and prognosis.J Clin Oncol 16, no. 9 (September 1998): 3158–68. https://doi.org/10.1200/JCO.1998.16.9.3158.
Kirsch DG, Kastan MB. Tumor-suppressor p53: implications for tumor development and prognosis. J Clin Oncol. 1998 Sep;16(9):3158–68.
Kirsch, D. G., and M. B. Kastan. “Tumor-suppressor p53: implications for tumor development and prognosis.J Clin Oncol, vol. 16, no. 9, Sept. 1998, pp. 3158–68. Pubmed, doi:10.1200/JCO.1998.16.9.3158.
Kirsch DG, Kastan MB. Tumor-suppressor p53: implications for tumor development and prognosis. J Clin Oncol. 1998 Sep;16(9):3158–3168.

Published In

J Clin Oncol

DOI

ISSN

0732-183X

Publication Date

September 1998

Volume

16

Issue

9

Start / End Page

3158 / 3168

Location

United States

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Prognosis
  • Oncology & Carcinogenesis
  • Neoplasms
  • Mutation
  • Humans
  • Genes, p53
  • Cell Cycle
  • Apoptosis
  • 3211 Oncology and carcinogenesis