Future of early detection of lung cancer: the role of mouse models.
Early detection represents one of the most promising approaches to improving lung cancer survival. To date, no screening strategies have been shown to decrease mortality from the disease. Furthermore, no reliable circulating biomarkers of lung cancer have been identified that allow early diagnosis. With the advent of gene targeting technology, new genetically engineered mouse models of lung cancer closely recapitulate the pathobiology of human disease. These mouse models have enabled novel approaches to early detection, including the identification of cancer-associated serum markers using proteomic technologies and the development of new molecular imaging tools. The application of innovative technologies to accurate mouse models promises to accelerate the discovery of new molecular targets and imaging biomarkers for the early detection of lung cancer.
Duke Scholars
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Related Subject Headings
- Oncology & Carcinogenesis
- Mice
- Lung Neoplasms
- Genetic Engineering
- Disease Models, Animal
- Diagnostic Imaging
- Biomarkers, Tumor
- Animals
- 3211 Oncology and carcinogenesis
- 3202 Clinical sciences
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Oncology & Carcinogenesis
- Mice
- Lung Neoplasms
- Genetic Engineering
- Disease Models, Animal
- Diagnostic Imaging
- Biomarkers, Tumor
- Animals
- 3211 Oncology and carcinogenesis
- 3202 Clinical sciences