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Effect of maternal smoking on fetal catecholamine concentrations at birth.

Publication ,  Journal Article
Oncken, CA; Henry, KM; Campbell, WA; Kuhn, CM; Slotkin, TA; Kranzler, HR
Published in: Pediatr Res
January 2003

The aim of this study was to compare catecholamine concentrations in the fetal umbilical artery cord blood from the offspring of smokers versus the offspring of nonsmokers. Pregnant women who were self-identified as smokers (>/=10 cigarettes per day throughout pregnancy) or nonsmokers were recruited for study participation. Maternal blood was collected for cotinine concentrations. Umbilical artery cord blood was collected at delivery for arterial pH and catecholamine concentrations. Cord blood was obtained from 51 subjects, including 21 smokers and 30 nonsmokers. Median epinephrine concentrations [304 pg/mL versus 597 pg/mL (Mann-Whitney U = 170; p = 0.006)] and median norepinephrine concentrations [3148 pg/mL versus 6558 pg/mL (Mann-Whitney U = 191; p = 0.006)] were significantly lower in smokers compared with nonsmokers, respectively. After controlling for gestational age, route of delivery, and arterial pH, log-transformed epinephrine concentrations between smokers and nonsmokers were statistically significant (p = 0.03), with a similar trend for log-transformed norepinephrine concentrations (p = 0.07). Analyses of the data using cotinine <20 ng/mL to classify nonsmokers also showed differences in epinephrine concentrations between groups (p = 0.02). These results are consistent with results from animal studies showing that catecholamine concentrations may be affected by prenatal nicotine exposure. Further studies are needed to validate these findings and to examine the specific mechanism by which these differences may arise.

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Published In

Pediatr Res

DOI

ISSN

0031-3998

Publication Date

January 2003

Volume

53

Issue

1

Start / End Page

119 / 124

Location

United States

Related Subject Headings

  • Smoking
  • Pregnancy
  • Pediatrics
  • Maternal Exposure
  • Infant, Newborn
  • Humans
  • Female
  • Catecholamines
  • Blood Gas Analysis
  • Adult
 

Citation

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Oncken, C. A., Henry, K. M., Campbell, W. A., Kuhn, C. M., Slotkin, T. A., & Kranzler, H. R. (2003). Effect of maternal smoking on fetal catecholamine concentrations at birth. Pediatr Res, 53(1), 119–124. https://doi.org/10.1203/00006450-200301000-00020
Oncken, Cheryl A., Kerrie M. Henry, Winston A. Campbell, Cynthia M. Kuhn, Theodore A. Slotkin, and Henry R. Kranzler. “Effect of maternal smoking on fetal catecholamine concentrations at birth.Pediatr Res 53, no. 1 (January 2003): 119–24. https://doi.org/10.1203/00006450-200301000-00020.
Oncken CA, Henry KM, Campbell WA, Kuhn CM, Slotkin TA, Kranzler HR. Effect of maternal smoking on fetal catecholamine concentrations at birth. Pediatr Res. 2003 Jan;53(1):119–24.
Oncken, Cheryl A., et al. “Effect of maternal smoking on fetal catecholamine concentrations at birth.Pediatr Res, vol. 53, no. 1, Jan. 2003, pp. 119–24. Pubmed, doi:10.1203/00006450-200301000-00020.
Oncken CA, Henry KM, Campbell WA, Kuhn CM, Slotkin TA, Kranzler HR. Effect of maternal smoking on fetal catecholamine concentrations at birth. Pediatr Res. 2003 Jan;53(1):119–124.

Published In

Pediatr Res

DOI

ISSN

0031-3998

Publication Date

January 2003

Volume

53

Issue

1

Start / End Page

119 / 124

Location

United States

Related Subject Headings

  • Smoking
  • Pregnancy
  • Pediatrics
  • Maternal Exposure
  • Infant, Newborn
  • Humans
  • Female
  • Catecholamines
  • Blood Gas Analysis
  • Adult