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Sodium and water regulation in a patient with cerebral salt wasting.

Publication ,  Journal Article
Diringer, M; Ladenson, PW; Borel, C; Hart, GK; Kirsch, JR; Hanley, DF
Published in: Arch Neurol
August 1989

Hyponatremia, in patients with central nervous system disease, can be attributable to impaired free water excretion (syndrome of inappropriate secretion of antidiuretic hormone) or to excessive sodium excretion (cerebral salt wasting). We present a patient with a parietal glioma and hyponatremia characterized by salt wasting and dehydration. Rehydration and sodium repletion corrected the sodium and volume deficits; withdrawal of supplemental sodium resulted in recurrence of dehydration and hyponatremia. We determined sodium and water balance and measured plasma atriopeptin, antidiuretic hormone, and aldosterone. Plasma atriopeptin ranged from 8 to 44 pg/mL (normal, less than 45 pg/mL); antidiuretic hormone was not elevated at 4 to 5 pg/mL, and aldosterone was slightly elevated at 1040.25 pmol/L. The concentrations of these hormones could not directly explain the natriuresis; interactions with neural or other humoral factors may be involved. In evaluating such patients, careful attention to sodium and water balance is important to guide appropriate therapy.

Duke Scholars

Published In

Arch Neurol

DOI

ISSN

0003-9942

Publication Date

August 1989

Volume

46

Issue

8

Start / End Page

928 / 930

Location

United States

Related Subject Headings

  • Water-Electrolyte Balance
  • Vasopressins
  • Sodium
  • Neurology & Neurosurgery
  • Male
  • Hyponatremia
  • Humans
  • Glioma
  • Dehydration
  • Brain Neoplasms
 

Citation

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Diringer, M., Ladenson, P. W., Borel, C., Hart, G. K., Kirsch, J. R., & Hanley, D. F. (1989). Sodium and water regulation in a patient with cerebral salt wasting. Arch Neurol, 46(8), 928–930. https://doi.org/10.1001/archneur.1989.00520440124031
Diringer, M., P. W. Ladenson, C. Borel, G. K. Hart, J. R. Kirsch, and D. F. Hanley. “Sodium and water regulation in a patient with cerebral salt wasting.Arch Neurol 46, no. 8 (August 1989): 928–30. https://doi.org/10.1001/archneur.1989.00520440124031.
Diringer M, Ladenson PW, Borel C, Hart GK, Kirsch JR, Hanley DF. Sodium and water regulation in a patient with cerebral salt wasting. Arch Neurol. 1989 Aug;46(8):928–30.
Diringer, M., et al. “Sodium and water regulation in a patient with cerebral salt wasting.Arch Neurol, vol. 46, no. 8, Aug. 1989, pp. 928–30. Pubmed, doi:10.1001/archneur.1989.00520440124031.
Diringer M, Ladenson PW, Borel C, Hart GK, Kirsch JR, Hanley DF. Sodium and water regulation in a patient with cerebral salt wasting. Arch Neurol. 1989 Aug;46(8):928–930.

Published In

Arch Neurol

DOI

ISSN

0003-9942

Publication Date

August 1989

Volume

46

Issue

8

Start / End Page

928 / 930

Location

United States

Related Subject Headings

  • Water-Electrolyte Balance
  • Vasopressins
  • Sodium
  • Neurology & Neurosurgery
  • Male
  • Hyponatremia
  • Humans
  • Glioma
  • Dehydration
  • Brain Neoplasms