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Relapse in Guillain-Barré syndrome after treatment with human immune globulin.

Publication ,  Journal Article
Irani, DN; Cornblath, DR; Chaudhry, V; Borel, C; Hanley, DF
Published in: Neurology
May 1993

Seven adult patients received human immune globulin intravenously as initial therapy for Guillain-Barré syndrome. Although all patients initially stabilized or improved, five patients deteriorated 1 to 16 days after completion of treatment. In all five patients, clinical worsening included loss of at least one functional grade together with a decreased forced vital capacity. We subsequently treated each patient with a course of plasma exchange, which led to varying degrees of clinical improvement in four. In contrast to previously reported relapse rates for Guillain-Barré syndrome, our experience suggests that clinically significant relapses may occur in patients more often following human immune globulin therapy than after either plasma exchange or no therapy.

Duke Scholars

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

May 1993

Volume

43

Issue

5

Start / End Page

872 / 875

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Recurrence
  • Polyradiculoneuropathy
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Infusions, Intravenous
  • Immunoglobulins
  • Immunization, Passive
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Irani, D. N., Cornblath, D. R., Chaudhry, V., Borel, C., & Hanley, D. F. (1993). Relapse in Guillain-Barré syndrome after treatment with human immune globulin. Neurology, 43(5), 872–875. https://doi.org/10.1212/wnl.43.5.872
Irani, D. N., D. R. Cornblath, V. Chaudhry, C. Borel, and D. F. Hanley. “Relapse in Guillain-Barré syndrome after treatment with human immune globulin.Neurology 43, no. 5 (May 1993): 872–75. https://doi.org/10.1212/wnl.43.5.872.
Irani DN, Cornblath DR, Chaudhry V, Borel C, Hanley DF. Relapse in Guillain-Barré syndrome after treatment with human immune globulin. Neurology. 1993 May;43(5):872–5.
Irani, D. N., et al. “Relapse in Guillain-Barré syndrome after treatment with human immune globulin.Neurology, vol. 43, no. 5, May 1993, pp. 872–75. Pubmed, doi:10.1212/wnl.43.5.872.
Irani DN, Cornblath DR, Chaudhry V, Borel C, Hanley DF. Relapse in Guillain-Barré syndrome after treatment with human immune globulin. Neurology. 1993 May;43(5):872–875.

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

May 1993

Volume

43

Issue

5

Start / End Page

872 / 875

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Recurrence
  • Polyradiculoneuropathy
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Infusions, Intravenous
  • Immunoglobulins
  • Immunization, Passive
  • Humans