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The use of locomotor activity as a behavioral screen for neuronal damage following transient forebrain ischemia in gerbils.

Publication ,  Journal Article
Mileson, BE; Schwartz, RD
Published in: Neurosci Lett
July 8, 1991

Five min bilateral carotid artery occlusion (BCO) in gerbils results in selective degeneration of neurons in the hippocampus, striatum and cortex, and an increase in spontaneous locomotor activity. These phenomena were examined to determine if an association could be made between the site or degree of neuronal degeneration and the increase in locomotor activity. The distance traveled by the BCO gerbils in a novel cage 1, 4, and 28 days after a 5 min occlusion was significantly greater than control. The extensive pyramidal cell damage in the CA1 region of the hippocampus in BCO gerbils was associated with the significant increase in locomotor activity. The increase in locomotor activity did not correlate with either the striatal or cortical damage present. The increase in gerbil locomotor activity following a 5 min BCO can be used as a predictor of CA1 damage, but not as a predictor of striatal or cortical damage.

Duke Scholars

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

July 8, 1991

Volume

128

Issue

1

Start / End Page

71 / 76

Location

Ireland

Related Subject Headings

  • Neurons
  • Nerve Degeneration
  • Motor Activity
  • Male
  • Ischemic Attack, Transient
  • Hippocampus
  • Gerbillinae
  • Corpus Striatum
  • Cerebral Cortex
  • Behavior, Animal
 

Citation

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Mileson, B. E., & Schwartz, R. D. (1991). The use of locomotor activity as a behavioral screen for neuronal damage following transient forebrain ischemia in gerbils. Neurosci Lett, 128(1), 71–76. https://doi.org/10.1016/0304-3940(91)90762-i
Mileson, B. E., and R. D. Schwartz. “The use of locomotor activity as a behavioral screen for neuronal damage following transient forebrain ischemia in gerbils.Neurosci Lett 128, no. 1 (July 8, 1991): 71–76. https://doi.org/10.1016/0304-3940(91)90762-i.
Mileson, B. E., and R. D. Schwartz. “The use of locomotor activity as a behavioral screen for neuronal damage following transient forebrain ischemia in gerbils.Neurosci Lett, vol. 128, no. 1, July 1991, pp. 71–76. Pubmed, doi:10.1016/0304-3940(91)90762-i.
Journal cover image

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

July 8, 1991

Volume

128

Issue

1

Start / End Page

71 / 76

Location

Ireland

Related Subject Headings

  • Neurons
  • Nerve Degeneration
  • Motor Activity
  • Male
  • Ischemic Attack, Transient
  • Hippocampus
  • Gerbillinae
  • Corpus Striatum
  • Cerebral Cortex
  • Behavior, Animal