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Presynaptic nicotinic cholinergic receptors labeled by [3H]acetylcholine on catecholamine and serotonin axons in brain.

Publication ,  Journal Article
Schwartz, RD; Lehmann, J; Kellar, KJ
Published in: J Neurochem
May 1984

Nicotinic cholinergic receptor binding sites labeled by [3H]acetylcholine were measured in the cerebral cortices, thalami, striata, and hypothalami of rats lesioned by intraventricular injection of either 6-hydroxydopamine or 5, 7-dihydroxytryptamine. In addition, [3H]acetylcholine binding sites were measured in the cerebral cortices of rats lesioned by injection of ibotenic acid into the nucleus basalis magnocellularis. [3H]Acetylcholine binding was significantly decreased in the striata and hypothalami of both 6-hydroxydopamine- and 5,7-dihydroxytryptamine-lesioned rats. There was no change in binding in the cortex or thalamus by either lesion. Ibotenic acid lesions of the nucleus basalis magnocellularis, which projects cholinergic axons to the cortex, did not alter [3H]acetylcholine binding. These results provide evidence for a presynaptic location of nicotinic cholinergic binding sites on catecholamine and serotonin axons in the striatum and hypothalamus.

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Published In

J Neurochem

DOI

ISSN

0022-3042

Publication Date

May 1984

Volume

42

Issue

5

Start / End Page

1495 / 1498

Location

England

Related Subject Headings

  • Synapses
  • Serotonin
  • Receptors, Nicotinic
  • Rats, Inbred Strains
  • Rats
  • Organ Specificity
  • Neurology & Neurosurgery
  • Male
  • Kinetics
  • Ibotenic Acid
 

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Schwartz, R. D., Lehmann, J., & Kellar, K. J. (1984). Presynaptic nicotinic cholinergic receptors labeled by [3H]acetylcholine on catecholamine and serotonin axons in brain. J Neurochem, 42(5), 1495–1498. https://doi.org/10.1111/j.1471-4159.1984.tb02818.x
Schwartz, R. D., J. Lehmann, and K. J. Kellar. “Presynaptic nicotinic cholinergic receptors labeled by [3H]acetylcholine on catecholamine and serotonin axons in brain.J Neurochem 42, no. 5 (May 1984): 1495–98. https://doi.org/10.1111/j.1471-4159.1984.tb02818.x.
Schwartz, R. D., et al. “Presynaptic nicotinic cholinergic receptors labeled by [3H]acetylcholine on catecholamine and serotonin axons in brain.J Neurochem, vol. 42, no. 5, May 1984, pp. 1495–98. Pubmed, doi:10.1111/j.1471-4159.1984.tb02818.x.
Journal cover image

Published In

J Neurochem

DOI

ISSN

0022-3042

Publication Date

May 1984

Volume

42

Issue

5

Start / End Page

1495 / 1498

Location

England

Related Subject Headings

  • Synapses
  • Serotonin
  • Receptors, Nicotinic
  • Rats, Inbred Strains
  • Rats
  • Organ Specificity
  • Neurology & Neurosurgery
  • Male
  • Kinetics
  • Ibotenic Acid