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Serotonin-related gene polymorphisms and central nervous system serotonin function.

Publication ,  Journal Article
Williams, RB; Marchuk, DA; Gadde, KM; Barefoot, JC; Grichnik, K; Helms, MJ; Kuhn, CM; Lewis, JG; Schanberg, SM; Stafford-Smith, M; Suarez, EC ...
Published in: Neuropsychopharmacology
March 2003

Central nervous system (CNS) serotonergic function affects a wide range of biological and behavioral functions affecting health and disease. Our objective in this study was to determine whether functional polymorphisms of the genes that encode for the serotonin transporter promoter (5HTTLPR) and monoamine oxidase A (MAOA-uVNTR) are associated with CNS serotonin turnover-indexed by cerebrospinal fluid levels of 5-hydroxyindoleacetic acid (5-HIAA)-in a community sample of healthy adults. Subjects were 165 community volunteers without current medical or psychiatric illness, stratified with respect to ethnicity, gender, and socioeconomic status who underwent inpatient evaluation in the General Clinical Research Center of a university medical center. A significant ethnicity x genotype interaction (P=0.008) indicated that, compared to the long/long and long/short genotypes, the 5HTTLPR short/short genotype was associated with higher CSF 5-HIAA levels in African Americans, but with lower levels in Caucasians. A gender x genotype interaction (P=0.04) indicated that 5HTTLPR short/short genotype was associated with higher 5-HIAA levels in women but with lower levels in men. MAOA-uVNTR 3.5 and 4 repeat alleles were associated with higher 5-HIAA (P=0.03) levels in men, but were unrelated to 5-HIAA levels in women. These findings suggest that effects of serotonin-related gene polymorphisms on CNS serotonergic function vary as a function of both ethnicity and gender. Further research will be required to determine the mechanism(s) underlying these differential effects. In the meanwhile, both ethnicity and gender should be taken into account in research evaluating effects of these and related polymorphisms on CNS serotonergic function, as well as the broad range of biological and behavioral functions that are regulated by CNS serotonergic function.

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Published In

Neuropsychopharmacology

DOI

ISSN

0893-133X

Publication Date

March 2003

Volume

28

Issue

3

Start / End Page

533 / 541

Location

England

Related Subject Headings

  • Socioeconomic Factors
  • Sex Factors
  • Serotonin Plasma Membrane Transport Proteins
  • Serotonin
  • Psychiatry
  • Polymorphism, Genetic
  • Nerve Tissue Proteins
  • Monoamine Oxidase
  • Middle Aged
  • Membrane Transport Proteins
 

Citation

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Williams, R. B., Marchuk, D. A., Gadde, K. M., Barefoot, J. C., Grichnik, K., Helms, M. J., … Siegler, I. C. (2003). Serotonin-related gene polymorphisms and central nervous system serotonin function. Neuropsychopharmacology, 28(3), 533–541. https://doi.org/10.1038/sj.npp.1300054
Williams, Redford B., Douglas A. Marchuk, Kishore M. Gadde, John C. Barefoot, Katherine Grichnik, Michael J. Helms, Cynthia M. Kuhn, et al. “Serotonin-related gene polymorphisms and central nervous system serotonin function.Neuropsychopharmacology 28, no. 3 (March 2003): 533–41. https://doi.org/10.1038/sj.npp.1300054.
Williams RB, Marchuk DA, Gadde KM, Barefoot JC, Grichnik K, Helms MJ, et al. Serotonin-related gene polymorphisms and central nervous system serotonin function. Neuropsychopharmacology. 2003 Mar;28(3):533–41.
Williams, Redford B., et al. “Serotonin-related gene polymorphisms and central nervous system serotonin function.Neuropsychopharmacology, vol. 28, no. 3, Mar. 2003, pp. 533–41. Pubmed, doi:10.1038/sj.npp.1300054.
Williams RB, Marchuk DA, Gadde KM, Barefoot JC, Grichnik K, Helms MJ, Kuhn CM, Lewis JG, Schanberg SM, Stafford-Smith M, Suarez EC, Clary GL, Svenson IK, Siegler IC. Serotonin-related gene polymorphisms and central nervous system serotonin function. Neuropsychopharmacology. 2003 Mar;28(3):533–541.
Journal cover image

Published In

Neuropsychopharmacology

DOI

ISSN

0893-133X

Publication Date

March 2003

Volume

28

Issue

3

Start / End Page

533 / 541

Location

England

Related Subject Headings

  • Socioeconomic Factors
  • Sex Factors
  • Serotonin Plasma Membrane Transport Proteins
  • Serotonin
  • Psychiatry
  • Polymorphism, Genetic
  • Nerve Tissue Proteins
  • Monoamine Oxidase
  • Middle Aged
  • Membrane Transport Proteins