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Central nervous system serotonin function and cardiovascular responses to stress.

Publication ,  Journal Article
Williams, RB; Marchuk, DA; Gadde, KM; Barefoot, JC; Grichnik, K; Helms, MJ; Kuhn, CM; Lewis, JG; Schanberg, SM; Stafford-Smith, M; Suarez, EC ...
Published in: Psychosom Med
2001

OBJECTIVE: The objective of this study was to evaluate the impact of indices of central nervous system (CNS) serotonin function on cardiovascular reactivity to mental stress. METHODS: Lumbar puncture was performed on 54 healthy volunteers to obtain cerebrospinal fluid (CSF) for determination of 5-hydroxyindoleacetic acid (5HIAA) levels. Genotypes were determined with respect to a functional polymorphism of the serotonin transporter gene promoter region (5HTTLPR). Subjects then underwent mental stress testing. RESULTS: Persons with one or two long (l) 5HTTLPR alleles had CSF levels of the major serotonin metabolite, 5HIAA, that were 50% higher than those of persons with the s/s 5HTTLPR genotype. Persons with one or two l alleles or higher CSF 5HIAA levels also exhibited greater blood pressure and heart rate responses to a mental stress protocol. CONCLUSIONS: These findings suggest the 5HTTLPR polymorphism affects CNS serotonin function, and they are consistent with the general hypothesis that CNS serotonin function is involved in the regulation of potentially health-damaging biobehavioral characteristics. In particular, the l allele could contribute, through its association with increased cardiovascular reactivity to stress, to increased risk of cardiovascular disease.

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Published In

Psychosom Med

DOI

ISSN

0033-3174

Publication Date

2001

Volume

63

Issue

2

Start / End Page

300 / 305

Location

United States

Related Subject Headings

  • Stress, Psychological
  • Serotonin Plasma Membrane Transport Proteins
  • Serotonin
  • Psychiatry
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Nerve Tissue Proteins
  • Middle Aged
  • Membrane Transport Proteins
  • Membrane Glycoproteins
 

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Williams, R. B., Marchuk, D. A., Gadde, K. M., Barefoot, J. C., Grichnik, K., Helms, M. J., … Siegler, I. C. (2001). Central nervous system serotonin function and cardiovascular responses to stress. Psychosom Med, 63(2), 300–305. https://doi.org/10.1097/00006842-200103000-00016
Williams, R. B., D. A. Marchuk, K. M. Gadde, J. C. Barefoot, K. Grichnik, M. J. Helms, C. M. Kuhn, et al. “Central nervous system serotonin function and cardiovascular responses to stress.Psychosom Med 63, no. 2 (2001): 300–305. https://doi.org/10.1097/00006842-200103000-00016.
Williams RB, Marchuk DA, Gadde KM, Barefoot JC, Grichnik K, Helms MJ, et al. Central nervous system serotonin function and cardiovascular responses to stress. Psychosom Med. 2001;63(2):300–5.
Williams, R. B., et al. “Central nervous system serotonin function and cardiovascular responses to stress.Psychosom Med, vol. 63, no. 2, 2001, pp. 300–05. Pubmed, doi:10.1097/00006842-200103000-00016.
Williams RB, Marchuk DA, Gadde KM, Barefoot JC, Grichnik K, Helms MJ, Kuhn CM, Lewis JG, Schanberg SM, Stafford-Smith M, Suarez EC, Clary GL, Svenson IK, Siegler IC. Central nervous system serotonin function and cardiovascular responses to stress. Psychosom Med. 2001;63(2):300–305.

Published In

Psychosom Med

DOI

ISSN

0033-3174

Publication Date

2001

Volume

63

Issue

2

Start / End Page

300 / 305

Location

United States

Related Subject Headings

  • Stress, Psychological
  • Serotonin Plasma Membrane Transport Proteins
  • Serotonin
  • Psychiatry
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Nerve Tissue Proteins
  • Middle Aged
  • Membrane Transport Proteins
  • Membrane Glycoproteins