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Behavioural testing and histological assessments of rabbit spinal cord following intrathecal administration of ondansetron.

Publication ,  Journal Article
Lacassie, HJ; Schultz, JR; Cummings, TJ; Morris, R; Trasti, SL; Reynolds, JD
Published in: Clin Exp Pharmacol Physiol
September 2006

1. Intrathecal injection of ondansetron has the potential to reduce opioid-related side-effects. The aim of the present study was to determine whether this route of administration produces neuraxial injury. 2. Adult, non-pregnant female New Zealand white rabbits received a single bolus injection of a low (40 microg) or high (4.0 mg) dose of ondansetron into the intrathecal space between the 4th and 5th lumbar vertebrae. In some cases, ondansetron was coadministered with morphine (5 microg/kg). Control animals received a bolus injection of normal saline. Behavioural assessments were conducted at 1 and 24 h to determine overt changes in arousal and mobility, followed by histological evaluation of the excised spinal cord. 3. Of 45 animals investigated, 10 rabbits exhibited modest behavioural evidence of spinal injury, the incidence of which was equally distributed between the treatment groups. Haematoxylin and eosin, along with HAM56, staining of cross-sections of the cervical, thoracic and upper and lower lumbar areas revealed mild signs of inflammation. This, too, was equally distributed between the treatment groups, suggesting that any observed neuraxial injury was the result of needle trauma and not ondansetron neurotoxicity. 4. Collectively, these negative findings support conducting further experiments to fully assess the clinical usefulness of intrathecal ondansetron administration.

Duke Scholars

Published In

Clin Exp Pharmacol Physiol

DOI

ISSN

0305-1870

Publication Date

September 2006

Volume

33

Issue

9

Start / End Page

798 / 801

Location

Australia

Related Subject Headings

  • Spinal Cord Injuries
  • Spinal Cord
  • Rabbits
  • Physiology
  • Ondansetron
  • Motor Activity
  • Morphine
  • Injections, Spinal
  • Female
  • Drug Combinations
 

Citation

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Lacassie, H. J., Schultz, J. R., Cummings, T. J., Morris, R., Trasti, S. L., & Reynolds, J. D. (2006). Behavioural testing and histological assessments of rabbit spinal cord following intrathecal administration of ondansetron. Clin Exp Pharmacol Physiol, 33(9), 798–801. https://doi.org/10.1111/j.1440-1681.2006.04442.x
Lacassie, Hector J., John R. Schultz, Thomas J. Cummings, Richard Morris, Scott L. Trasti, and James D. Reynolds. “Behavioural testing and histological assessments of rabbit spinal cord following intrathecal administration of ondansetron.Clin Exp Pharmacol Physiol 33, no. 9 (September 2006): 798–801. https://doi.org/10.1111/j.1440-1681.2006.04442.x.
Lacassie HJ, Schultz JR, Cummings TJ, Morris R, Trasti SL, Reynolds JD. Behavioural testing and histological assessments of rabbit spinal cord following intrathecal administration of ondansetron. Clin Exp Pharmacol Physiol. 2006 Sep;33(9):798–801.
Lacassie, Hector J., et al. “Behavioural testing and histological assessments of rabbit spinal cord following intrathecal administration of ondansetron.Clin Exp Pharmacol Physiol, vol. 33, no. 9, Sept. 2006, pp. 798–801. Pubmed, doi:10.1111/j.1440-1681.2006.04442.x.
Lacassie HJ, Schultz JR, Cummings TJ, Morris R, Trasti SL, Reynolds JD. Behavioural testing and histological assessments of rabbit spinal cord following intrathecal administration of ondansetron. Clin Exp Pharmacol Physiol. 2006 Sep;33(9):798–801.
Journal cover image

Published In

Clin Exp Pharmacol Physiol

DOI

ISSN

0305-1870

Publication Date

September 2006

Volume

33

Issue

9

Start / End Page

798 / 801

Location

Australia

Related Subject Headings

  • Spinal Cord Injuries
  • Spinal Cord
  • Rabbits
  • Physiology
  • Ondansetron
  • Motor Activity
  • Morphine
  • Injections, Spinal
  • Female
  • Drug Combinations