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The effects of aprotinin on outcome from cerebral ischemia in the rat.

Publication ,  Journal Article
Grocott, HP; Sheng, H; Miura, Y; Sarraf-Yazdi, S; Mackensen, GB; Pearlstein, RD; Warner, DS
Published in: Anesth Analg
January 1999

UNLABELLED: The administration of aprotinin has been associated with a reduction in cardiac surgery-related stroke. Intrinsic neuroprotective properties of this drug have not been evaluated in laboratory outcome models of cerebral ischemia. The purpose of this study was to determine whether aprotinin exhibits neuroprotective effects against either global or focal cerebral ischemia in the rat. Fasted rats were administered aprotinin (30,000 or 60,000 KIU/kg) or vehicle (0.9% NaCl) IV before global ischemia (10 min bilateral carotid occlusion with mean arterial pressure 30 mm Hg) or focal ischemia (75 min of transient middle cerebral artery occlusion [MCAO]). Five days after global ischemia, the percentage of dead hippocampal CA1 neurons (mean +/- SD) was similar among the groups (small-dose aprotinin: 49+/-31, n = 15; large-dose aprotinin: 55+/-31, n = 13; vehicle: 47+/-31, n = 16; P = 0.74). After 7 days' recovery from MCAO, no difference among the groups was observed for either neurologic score (P = 0.99) or cerebral infarct volume (small-dose aprotinin: 136+/-80 mm3, n = 23; large-dose aprotinin: 132+/-101 mm3, n = 11; vehicle: 121+/-81 mm3, n = 21; P = 0.87). IMPLICATIONS: Aprotinin offers no neuroprotection against either global or focal cerebral ischemia in the rat when administered as a single preischemic bolus.

Duke Scholars

Published In

Anesth Analg

DOI

ISSN

0003-2999

Publication Date

January 1999

Volume

88

Issue

1

Start / End Page

1 / 7

Location

United States

Related Subject Headings

  • Serine Proteinase Inhibitors
  • Rats, Sprague-Dawley
  • Rats
  • Neurons
  • Male
  • Ischemic Attack, Transient
  • Hippocampus
  • Cerebral Infarction
  • Cell Death
  • Arterial Occlusive Diseases
 

Citation

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Grocott, H. P., Sheng, H., Miura, Y., Sarraf-Yazdi, S., Mackensen, G. B., Pearlstein, R. D., & Warner, D. S. (1999). The effects of aprotinin on outcome from cerebral ischemia in the rat. Anesth Analg, 88(1), 1–7. https://doi.org/10.1097/00000539-199901000-00001
Grocott, H. P., H. Sheng, Y. Miura, S. Sarraf-Yazdi, G. B. Mackensen, R. D. Pearlstein, and D. S. Warner. “The effects of aprotinin on outcome from cerebral ischemia in the rat.Anesth Analg 88, no. 1 (January 1999): 1–7. https://doi.org/10.1097/00000539-199901000-00001.
Grocott HP, Sheng H, Miura Y, Sarraf-Yazdi S, Mackensen GB, Pearlstein RD, et al. The effects of aprotinin on outcome from cerebral ischemia in the rat. Anesth Analg. 1999 Jan;88(1):1–7.
Grocott, H. P., et al. “The effects of aprotinin on outcome from cerebral ischemia in the rat.Anesth Analg, vol. 88, no. 1, Jan. 1999, pp. 1–7. Pubmed, doi:10.1097/00000539-199901000-00001.
Grocott HP, Sheng H, Miura Y, Sarraf-Yazdi S, Mackensen GB, Pearlstein RD, Warner DS. The effects of aprotinin on outcome from cerebral ischemia in the rat. Anesth Analg. 1999 Jan;88(1):1–7.

Published In

Anesth Analg

DOI

ISSN

0003-2999

Publication Date

January 1999

Volume

88

Issue

1

Start / End Page

1 / 7

Location

United States

Related Subject Headings

  • Serine Proteinase Inhibitors
  • Rats, Sprague-Dawley
  • Rats
  • Neurons
  • Male
  • Ischemic Attack, Transient
  • Hippocampus
  • Cerebral Infarction
  • Cell Death
  • Arterial Occlusive Diseases