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Aortic atheroma burden and cognitive dysfunction after coronary artery bypass graft surgery.

Publication ,  Journal Article
Bar-Yosef, S; Anders, M; Mackensen, GB; Ti, LK; Mathew, JP; Phillips-Bute, B; Messier, RH; Grocott, HP ...
Published in: Ann Thorac Surg
November 2004

BACKGROUND: Neurocognitive dysfunction (NCD) after coronary artery bypass graft (CABG) surgery is a common problem. Atherosclerotic disease of the aorta is a known risk factor for stroke after cardiac surgery, but its relationship to NCD is unclear. This study investigates the relationship between aortic atherosclerotic disease and NCD after CABG. PATIENTS AND METHODS: Patients undergoing primary elective CABG were enrolled in an ongoing investigation of NCD after CABG. Intraoperative transesophageal echocardiography (TEE) of the thoracic aorta was performed and analyzed off-line to quantify atheroma burden. Neurocognitive evaluation was performed, both preoperatively and at 6 weeks after surgery. Multivariable linear regression (controlling for age, years of education, and base line cognitive index) was used to determine the relationship between NCD and atheroma burden in the ascending, arch, and descending aorta. RESULTS: One hundred sixty-two patients who had a complete neurocognitive evaluation and adequate TEE images were studied. No significant relationship was found between NCD and atheroma burden in the ascending (p = 0.22), arch (p = 0.89) or descending aorta (p = 0.64). CONCLUSIONS: Although the etiology of NCD is likely multifactorial, our results suggest that aortic atherosclerosis may not be the primary factor in the pathogenesis of post-CABG cognitive changes.

Duke Scholars

Published In

Ann Thorac Surg

DOI

EISSN

1552-6259

Publication Date

November 2004

Volume

78

Issue

5

Start / End Page

1556 / 1562

Location

Netherlands

Related Subject Headings

  • Single-Blind Method
  • Respiratory System
  • Postoperative Complications
  • Neuropsychological Tests
  • Monitoring, Intraoperative
  • Middle Aged
  • Male
  • Intracranial Embolism
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
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Bar-Yosef, S., Anders, M., Mackensen, G. B., Ti, L. K., Mathew, J. P., Phillips-Bute, B., … Neurological Outcome Research Group and CARE Investigators of the Duke Heart Center, . (2004). Aortic atheroma burden and cognitive dysfunction after coronary artery bypass graft surgery. Ann Thorac Surg, 78(5), 1556–1562. https://doi.org/10.1016/j.athoracsur.2004.05.002
Bar-Yosef, Shahar, Marc Anders, G Burkhard Mackensen, Lian K. Ti, Joseph P. Mathew, Barbara Phillips-Bute, Robert H. Messier, Hilary P. Grocott, and Hilary P. Neurological Outcome Research Group and CARE Investigators of the Duke Heart Center. “Aortic atheroma burden and cognitive dysfunction after coronary artery bypass graft surgery.Ann Thorac Surg 78, no. 5 (November 2004): 1556–62. https://doi.org/10.1016/j.athoracsur.2004.05.002.
Bar-Yosef S, Anders M, Mackensen GB, Ti LK, Mathew JP, Phillips-Bute B, et al. Aortic atheroma burden and cognitive dysfunction after coronary artery bypass graft surgery. Ann Thorac Surg. 2004 Nov;78(5):1556–62.
Bar-Yosef, Shahar, et al. “Aortic atheroma burden and cognitive dysfunction after coronary artery bypass graft surgery.Ann Thorac Surg, vol. 78, no. 5, Nov. 2004, pp. 1556–62. Pubmed, doi:10.1016/j.athoracsur.2004.05.002.
Bar-Yosef S, Anders M, Mackensen GB, Ti LK, Mathew JP, Phillips-Bute B, Messier RH, Grocott HP, Neurological Outcome Research Group and CARE Investigators of the Duke Heart Center. Aortic atheroma burden and cognitive dysfunction after coronary artery bypass graft surgery. Ann Thorac Surg. 2004 Nov;78(5):1556–1562.
Journal cover image

Published In

Ann Thorac Surg

DOI

EISSN

1552-6259

Publication Date

November 2004

Volume

78

Issue

5

Start / End Page

1556 / 1562

Location

Netherlands

Related Subject Headings

  • Single-Blind Method
  • Respiratory System
  • Postoperative Complications
  • Neuropsychological Tests
  • Monitoring, Intraoperative
  • Middle Aged
  • Male
  • Intracranial Embolism
  • Humans
  • Female