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Moderate sedation for MRI in young children with autism.

Publication ,  Journal Article
Ross, AK; Hazlett, HC; Garrett, NT; Wilkerson, C; Piven, J
Published in: Pediatr Radiol
September 2005

UNLABELLED: Autism is a pervasive neurodevelopmental disorder. Because of the deficits associated with the condition, sedation of children with autism has been considered more challenging than sedation of other children. OBJECTIVE: To test this hypothesis, we compared children with autism against clinical controls to determine differences in requirements for moderate sedation for MRI. MATERIALS AND METHODS: Children ages 18-36 months with autism (group 1, n = 41) and children with no autistic behavior (group 2, n = 42) were sedated with a combination of pentobarbital and fentanyl per sedation service protocol. The sedation nurse was consistent for all patients, and all were sedated to achieve a Modified Ramsay Score of 4. Demographics and doses of sedatives were recorded and compared. RESULTS: There were no sedation failures in either group. Children in group 1 (autism) were significantly older than group 2 (32.02+/-3.6 months vs 28.16+/-6.7 months) and weighed significantly more (14.87+/-2.1 kg vs 13.42+/-2.2 kg). When compared on a per-kilogram basis, however, group 1 had a significantly lower fentanyl requirement than group 2 (1.25+/-0.55 mcg/kg vs 1.57+/-0.81 mcg/kg), but no significant difference was found in pentobarbital dosing between groups 1 and 2, respectively (4.92+/-0.92 mg/kg vs 5.21+/-1.6 mg/kg). CONCLUSION: Autistic children in this age range are not more difficult to sedate and do not require higher doses of sedative agents for noninvasive imaging studies.

Duke Scholars

Published In

Pediatr Radiol

DOI

ISSN

0301-0449

Publication Date

September 2005

Volume

35

Issue

9

Start / End Page

867 / 871

Location

Germany

Related Subject Headings

  • Retrospective Studies
  • Pentobarbital
  • Nuclear Medicine & Medical Imaging
  • Male
  • Magnetic Resonance Imaging
  • Infant
  • Hypnotics and Sedatives
  • Humans
  • Fentanyl
  • Female
 

Citation

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Ross, A. K., Hazlett, H. C., Garrett, N. T., Wilkerson, C., & Piven, J. (2005). Moderate sedation for MRI in young children with autism. Pediatr Radiol, 35(9), 867–871. https://doi.org/10.1007/s00247-005-1499-2
Ross, Allison Kinder, Heather Cody Hazlett, Nancy T. Garrett, Christy Wilkerson, and Joseph Piven. “Moderate sedation for MRI in young children with autism.Pediatr Radiol 35, no. 9 (September 2005): 867–71. https://doi.org/10.1007/s00247-005-1499-2.
Ross AK, Hazlett HC, Garrett NT, Wilkerson C, Piven J. Moderate sedation for MRI in young children with autism. Pediatr Radiol. 2005 Sep;35(9):867–71.
Ross, Allison Kinder, et al. “Moderate sedation for MRI in young children with autism.Pediatr Radiol, vol. 35, no. 9, Sept. 2005, pp. 867–71. Pubmed, doi:10.1007/s00247-005-1499-2.
Ross AK, Hazlett HC, Garrett NT, Wilkerson C, Piven J. Moderate sedation for MRI in young children with autism. Pediatr Radiol. 2005 Sep;35(9):867–871.
Journal cover image

Published In

Pediatr Radiol

DOI

ISSN

0301-0449

Publication Date

September 2005

Volume

35

Issue

9

Start / End Page

867 / 871

Location

Germany

Related Subject Headings

  • Retrospective Studies
  • Pentobarbital
  • Nuclear Medicine & Medical Imaging
  • Male
  • Magnetic Resonance Imaging
  • Infant
  • Hypnotics and Sedatives
  • Humans
  • Fentanyl
  • Female