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Sustained radiographic and clinical response in patient with bifrontal recurrent glioblastoma multiforme with intracerebral infusion of the recombinant targeted toxin TP-38: case study.

Publication ,  Journal Article
Sampson, JH; Reardon, DA; Friedman, AH; Friedman, HS; Coleman, RE; McLendon, RE; Pastan, I; Bigner, DD
Published in: Neuro Oncol
January 2005

Glioblastoma multiforme remains refractory to conventional therapy, and novel therapeutic modalities are desperately needed. TP-38 is a recombinant chimeric protein containing a genetically engineered form of the cytotoxic Pseudomonas exotoxin fused to transforming growth factor (TGF)-alpha. TGF-alpha binds with high affinity to the epidermal growth factor receptor, which is uniformly overexpressed in malignant gliomas, often because of gene amplification. Prior to therapy with TP-38, the patient described here was completely refractory to multiple other therapies, with radiographic and pathologic evidence of tumor progression. After therapy, she improved clinically, was weaned off steroids and anti-convulsants, and experienced a progressive decrease in enhancing tumor volume. Despite multiple prior recurrences, she has not progressed for >43 months after TP-38 therapy. Small remaining areas of enhancement demonstrate no evidence of tumor histologically and are hypometabolic on positron emission tomography. This report describes a dramatic and sustained clinical and radiographic response in a patient with a bifrontal glioblastoma multiforme treated with intratumoral infusion of a novel targeted toxin, TP-38.

Duke Scholars

Published In

Neuro Oncol

DOI

ISSN

1522-8517

Publication Date

January 2005

Volume

7

Issue

1

Start / End Page

90 / 96

Location

England

Related Subject Headings

  • Treatment Outcome
  • Transforming Growth Factor alpha
  • Recombinant Fusion Proteins
  • Pseudomonas aeruginosa
  • Oncology & Carcinogenesis
  • Middle Aged
  • Magnetic Resonance Imaging
  • Injections, Intraventricular
  • Humans
  • Glioblastoma
 

Citation

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ICMJE
MLA
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Sampson, J. H., Reardon, D. A., Friedman, A. H., Friedman, H. S., Coleman, R. E., McLendon, R. E., … Bigner, D. D. (2005). Sustained radiographic and clinical response in patient with bifrontal recurrent glioblastoma multiforme with intracerebral infusion of the recombinant targeted toxin TP-38: case study. Neuro Oncol, 7(1), 90–96. https://doi.org/10.1215/S1152851703000589
Sampson, John H., David A. Reardon, Allan H. Friedman, Henry S. Friedman, R Edward Coleman, Roger E. McLendon, Ira Pastan, and Darell D. Bigner. “Sustained radiographic and clinical response in patient with bifrontal recurrent glioblastoma multiforme with intracerebral infusion of the recombinant targeted toxin TP-38: case study.Neuro Oncol 7, no. 1 (January 2005): 90–96. https://doi.org/10.1215/S1152851703000589.
Sampson JH, Reardon DA, Friedman AH, Friedman HS, Coleman RE, McLendon RE, Pastan I, Bigner DD. Sustained radiographic and clinical response in patient with bifrontal recurrent glioblastoma multiforme with intracerebral infusion of the recombinant targeted toxin TP-38: case study. Neuro Oncol. 2005 Jan;7(1):90–96.
Journal cover image

Published In

Neuro Oncol

DOI

ISSN

1522-8517

Publication Date

January 2005

Volume

7

Issue

1

Start / End Page

90 / 96

Location

England

Related Subject Headings

  • Treatment Outcome
  • Transforming Growth Factor alpha
  • Recombinant Fusion Proteins
  • Pseudomonas aeruginosa
  • Oncology & Carcinogenesis
  • Middle Aged
  • Magnetic Resonance Imaging
  • Injections, Intraventricular
  • Humans
  • Glioblastoma