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Activity of high-dose cyclophosphamide in the treatment of childhood malignant gliomas.

Publication ,  Journal Article
McCowage, GB; Friedman, HS; Moghrabi, A; Kerby, T; Ferrell, L; Stewart, E; Duncan-Brown, M; Fuchs, HE; Tien, R; McLendon, RE; Meier, L ...
Published in: Med Pediatr Oncol
February 1998
Published version (DOI) Link to item

Seventeen patients less than or equal to 20 years of age with newly diagnosed (n = 10) or recurrent (n = 7) malignant gliomas (anaplastic astrocytoma and glioblastoma multiforme) were treated with cyclophosphamide in association with hematopoietic cytokines (GM-CSF or G-CSF). Cyclophosphamide was given at a dose of 2 g/m2 daily for 2 days at 4-week intervals. Toxicity consisted of grade IV neutropenia and thrombocytopenia in 95% and 48% of cycles, respectively. There were no cyclophosphamide-related cardiac, pulmonary, or urothelial toxicities observed. Four of 10 patients with newly diagnosed disease demonstrated responses (three complete and one partial responses; one CR was only of 2 months duration). None of the seven patients with recurrent tumors demonstrated a response. We conclude that high-dose cyclophosphamide warrants further evaluation in children with newly diagnosed malignant glioma.

Duke Scholars

Henry Seth Friedman
Author Henry Seth Friedman Neurosurgery, Neuro-Oncology
Herbert Edgar Fuchs
Author Herbert Edgar Fuchs Neurosurgery
Roger Edwin McLendon
Author Roger Edwin McLendon Pathology
Joanne Kurtzberg
Author Joanne Kurtzberg Pediatrics, Transplant and Cellular Therapy
David Michael Ashley
Author David Michael Ashley Neurosurgery

Published In

Med Pediatr Oncol

DOI

10.1002/(sici)1096-911x(199802)30:2<75::aid-mpo1>3.0.co;2-x

ISSN

0098-1532

Publication Date

February 1998

Volume

30

Issue

2

Start / End Page

75 / 80

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Male
  • Infant
  • Humans
  • Glioblastoma
  • Female
  • Cyclophosphamide
  • Child, Preschool
  • Child
  • Brain Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
NLM
McCowage, G. B., Friedman, H. S., Moghrabi, A., Kerby, T., Ferrell, L., Stewart, E., … Longee, D. C. (1998). Activity of high-dose cyclophosphamide in the treatment of childhood malignant gliomas. Med Pediatr Oncol, 30(2), 75–80. https://doi.org/10.1002/(sici)1096-911x(199802)30:2<75::aid-mpo1>3.0.co;2-x
McCowage, G. B., H. S. Friedman, A. Moghrabi, T. Kerby, L. Ferrell, E. Stewart, M. Duncan-Brown, et al. “Activity of high-dose cyclophosphamide in the treatment of childhood malignant gliomas.” Med Pediatr Oncol 30, no. 2 (February 1998): 75–80. https://doi.org/10.1002/(sici)1096-911x(199802)30:2<75::aid-mpo1>3.0.co;2-x.
McCowage GB, Friedman HS, Moghrabi A, Kerby T, Ferrell L, Stewart E, et al. Activity of high-dose cyclophosphamide in the treatment of childhood malignant gliomas. Med Pediatr Oncol. 1998 Feb;30(2):75–80.
McCowage, G. B., et al. “Activity of high-dose cyclophosphamide in the treatment of childhood malignant gliomas.” Med Pediatr Oncol, vol. 30, no. 2, Feb. 1998, pp. 75–80. Pubmed, doi:10.1002/(sici)1096-911x(199802)30:2<75::aid-mpo1>3.0.co;2-x.
McCowage GB, Friedman HS, Moghrabi A, Kerby T, Ferrell L, Stewart E, Duncan-Brown M, Fuchs HE, Tien R, McLendon RE, Meier L, Kurtzberg J, Ashley D, Colvin OM, Longee DC. Activity of high-dose cyclophosphamide in the treatment of childhood malignant gliomas. Med Pediatr Oncol. 1998 Feb;30(2):75–80.

Published In

Med Pediatr Oncol

DOI

10.1002/(sici)1096-911x(199802)30:2<75::aid-mpo1>3.0.co;2-x

ISSN

0098-1532

Publication Date

February 1998

Volume

30

Issue

2

Start / End Page

75 / 80

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Male
  • Infant
  • Humans
  • Glioblastoma
  • Female
  • Cyclophosphamide
  • Child, Preschool
  • Child
  • Brain Neoplasms