Morphologic and molecular genetic aspects of oligodendroglial neoplasms.
Morphologic criteria for diagnosing oligodendrogliomas and for classifying them as well-differentiated (World Health Organization grade II) and anaplastic (World Health Organization grade III) are well recognized. Nevertheless, applying these guidelines to specific cases often reveals discrepancies among different observers. In addition, whether a given tumor also contains an astrocytic component may be debatable. Loss of heterozygosity studies have demonstrated that oligodendroglial neoplasms have a high incidence of loss of the 1p and 19q chromosomal arms. Although loss of heterozygosity for portions of 19q are sometimes seen in astrocytic neoplasms, these tumors seldom show complete loss of 19q accompanied by loss of 1p. Loss of 9p or homozygous deletion of the CDKN2 gene or both are associated with anaplastic oligodendrogliomas, whereas loss of 17p or TP53 gene mutations or both are frequent in astrocytomas, but rare in oligodendrogliomas. These observations suggest that molecular genetic parameters could provide an objective, reproducible framework for classifying oligodendroglial neoplasms.
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Related Subject Headings
- World Health Organization
- Tumor Suppressor Protein p53
- Oncology & Carcinogenesis
- Oligodendroglioma
- Nucleic Acid Hybridization
- Loss of Heterozygosity
- Karyotyping
- Humans
- Glioma
- Genes, p53
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- World Health Organization
- Tumor Suppressor Protein p53
- Oncology & Carcinogenesis
- Oligodendroglioma
- Nucleic Acid Hybridization
- Loss of Heterozygosity
- Karyotyping
- Humans
- Glioma
- Genes, p53