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Gliomatosis cerebri: cytologic and autopsy findings in a case involving the entire neuraxis.

Publication ,  Journal Article
Cummings, TJ; Hulette, CM; Longee, DC; Bottom, KS; McLendon, RE; Chu, CT
Published in: Clin Neuropathol
1999

We describe the case of a 7-year-old girl who was clinically diagnosed as having a pontine glioma based on magnetic resonance imaging studies. Neoplastic cells were identified upon cytologic examination of cerebrospinal fluid. Autopsy studies revealed an anaplastic astrocytoma (WHO grade III) diffusely infiltrating the cerebral hemispheres, brain stem, cerebellum, leptomeninges, and spinal cord to the level of the conus medullaris. The Ki-67 labeling index focally approached 30%. Although many of the neoplastic cells displayed elongated twisted nuclei reminiscent of microglia, these cells stained intensely for glial fibrillary acidic protein, supporting an astrocytic origin. Unusual features of this case of gliomatosis cerebri include involvement of the entire central neuraxis, correlation with pre-mortem lumbar puncture cytology, and a markedly elevated Ki-67 labeling index.

Duke Scholars

Published In

Clin Neuropathol

ISSN

0722-5091

Publication Date

1999

Volume

18

Issue

4

Start / End Page

190 / 197

Location

Germany

Related Subject Headings

  • Spinal Cord
  • Neurology & Neurosurgery
  • Magnetic Resonance Imaging
  • Ki-67 Antigen
  • Immunohistochemistry
  • Humans
  • Glioma
  • Glial Fibrillary Acidic Protein
  • Female
  • Child
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cummings, T. J., Hulette, C. M., Longee, D. C., Bottom, K. S., McLendon, R. E., & Chu, C. T. (1999). Gliomatosis cerebri: cytologic and autopsy findings in a case involving the entire neuraxis. Clin Neuropathol, 18(4), 190–197.
Cummings, T. J., C. M. Hulette, D. C. Longee, K. S. Bottom, R. E. McLendon, and C. T. Chu. “Gliomatosis cerebri: cytologic and autopsy findings in a case involving the entire neuraxis.Clin Neuropathol 18, no. 4 (1999): 190–97.
Cummings TJ, Hulette CM, Longee DC, Bottom KS, McLendon RE, Chu CT. Gliomatosis cerebri: cytologic and autopsy findings in a case involving the entire neuraxis. Clin Neuropathol. 1999;18(4):190–7.
Cummings, T. J., et al. “Gliomatosis cerebri: cytologic and autopsy findings in a case involving the entire neuraxis.Clin Neuropathol, vol. 18, no. 4, 1999, pp. 190–97.
Cummings TJ, Hulette CM, Longee DC, Bottom KS, McLendon RE, Chu CT. Gliomatosis cerebri: cytologic and autopsy findings in a case involving the entire neuraxis. Clin Neuropathol. 1999;18(4):190–197.

Published In

Clin Neuropathol

ISSN

0722-5091

Publication Date

1999

Volume

18

Issue

4

Start / End Page

190 / 197

Location

Germany

Related Subject Headings

  • Spinal Cord
  • Neurology & Neurosurgery
  • Magnetic Resonance Imaging
  • Ki-67 Antigen
  • Immunohistochemistry
  • Humans
  • Glioma
  • Glial Fibrillary Acidic Protein
  • Female
  • Child