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MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group.

Publication ,  Journal Article
Aldosari, N; Bigner, SH; Burger, PC; Becker, L; Kepner, JL; Friedman, HS; McLendon, RE
Published in: Arch Pathol Lab Med
May 2002

CONTEXT: Brain tumors are the most common solid tumor in childhood, and medulloblastoma is the most common malignant brain tumor in this age group. Cytogenetic abnormalities that have been described in childhood medulloblastoma include loss of 17p, amplification of MYCC (c-myc), amplification of MYCN (N-myc), and isochromosome 17q. Data on these tumors indicate that the frequency of MYCC amplification is 5% to 10%. Fluorescence in situ hybridization is a powerful tool for investigating these features on archival material. OBJECTIVES: To determine if intratumoral heterogeneity exists for MYCC and MYCN in medulloblastomas and if tumors with amplified MYCC or MYCN exhibit consistent histologic patterns. DESIGN: In this fluorescence in situ hybridization study, we investigated the frequency and prognostic significance of MYCC and MYCN amplification in 77 medulloblastomas derived from the Children's Oncology Group. RESULTS: MYCC amplification occurred in only 4 (5.2%) of 77 tumors. The 4 patients died of clinically aggressive neoplasms within 7 months of diagnosis. Similarly, 4 of 77 patients' tumors were found to exhibit MYCN amplification, but survival data are incomplete at present, therefore prognostic significance cannot be characterized. CONCLUSIONS: These data establish the frequency of MYCC amplification in a large cohort of children with medulloblastoma and further suggest that MYCC amplification may be a marker of poor prognosis. Intratumoral heterogeneity was identified for these oncogenes in that 1 patient's tumor exhibited evidence of both MYCN and MYCC amplification, and this patient experienced a shortened survival time.

Duke Scholars

Published In

Arch Pathol Lab Med

DOI

ISSN

0003-9985

Publication Date

May 2002

Volume

126

Issue

5

Start / End Page

540 / 544

Location

United States

Related Subject Headings

  • Survival Rate
  • Prognosis
  • Pathology
  • Medulloblastoma
  • Male
  • Infant
  • In Situ Hybridization, Fluorescence
  • In Situ Hybridization
  • Humans
  • Genes, myc
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Aldosari, N., Bigner, S. H., Burger, P. C., Becker, L., Kepner, J. L., Friedman, H. S., & McLendon, R. E. (2002). MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group. Arch Pathol Lab Med, 126(5), 540–544. https://doi.org/10.5858/2002-126-0540-MAMOAI
Aldosari, Naji, Sandra H. Bigner, Peter C. Burger, Laurence Becker, James L. Kepner, Henry S. Friedman, and Roger E. McLendon. “MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group.Arch Pathol Lab Med 126, no. 5 (May 2002): 540–44. https://doi.org/10.5858/2002-126-0540-MAMOAI.
Aldosari N, Bigner SH, Burger PC, Becker L, Kepner JL, Friedman HS, et al. MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group. Arch Pathol Lab Med. 2002 May;126(5):540–4.
Aldosari, Naji, et al. “MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group.Arch Pathol Lab Med, vol. 126, no. 5, May 2002, pp. 540–44. Pubmed, doi:10.5858/2002-126-0540-MAMOAI.
Aldosari N, Bigner SH, Burger PC, Becker L, Kepner JL, Friedman HS, McLendon RE. MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group. Arch Pathol Lab Med. 2002 May;126(5):540–544.

Published In

Arch Pathol Lab Med

DOI

ISSN

0003-9985

Publication Date

May 2002

Volume

126

Issue

5

Start / End Page

540 / 544

Location

United States

Related Subject Headings

  • Survival Rate
  • Prognosis
  • Pathology
  • Medulloblastoma
  • Male
  • Infant
  • In Situ Hybridization, Fluorescence
  • In Situ Hybridization
  • Humans
  • Genes, myc