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Fine-needle aspiration cytology of "ancient" schwannoma.

Publication ,  Journal Article
Dodd, LG; Marom, EM; Dash, RC; Matthews, MR; McLendon, RE
Published in: Diagn Cytopathol
May 1999

The term "ancient" schwannoma was proposed for a group of neural tumors showing degenerative changes and marked nuclear atypia. Prior to the realization that the observed atypia was a regressive phenomenon, many of these lesions were erroneously diagnosed as sarcomas. Fine-needle aspiration (FNA) cytologic material from five patients is included in this study. Tissue examined histologically included four resected tumors and 18 gauge core biopsies of one tumor. Aspirates of ancient schwannoma showed many of the same features as FNA of regular schwannoma: aggregates of spindled cells with indistinct cytoplasm and elongate nuclei with blunt point ends. The feature unique to these lesions was nuclear pleomorphism, which was identified in all aspirates. Nuclear inclusions were identified in all but one case. Cystic degeneration, xanthomatous changes, and perivascular sclerosis were identified in excised lesions. Ancient schwannomas show most of the FNA features of benign schwannomas but can demonstrate marked nuclear atypia. The FNA features of ancient schwannoma are important to note because of the potential to confuse this lesion with a more serious one such as sarcoma on FNA.

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Published In

Diagn Cytopathol

DOI

ISSN

8755-1039

Publication Date

May 1999

Volume

20

Issue

5

Start / End Page

307 / 311

Location

United States

Related Subject Headings

  • Pathology
  • Neurilemmoma
  • Nervous System Neoplasms
  • Middle Aged
  • Male
  • Humans
  • Female
  • Biopsy, Needle
  • Aged
  • Adult
 

Citation

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Dodd, L. G., Marom, E. M., Dash, R. C., Matthews, M. R., & McLendon, R. E. (1999). Fine-needle aspiration cytology of "ancient" schwannoma. Diagn Cytopathol, 20(5), 307–311. https://doi.org/10.1002/(sici)1097-0339(199905)20:5<307::aid-dc12>3.0.co;2-f
Dodd, L. G., E. M. Marom, R. C. Dash, M. R. Matthews, and R. E. McLendon. “Fine-needle aspiration cytology of "ancient" schwannoma.Diagn Cytopathol 20, no. 5 (May 1999): 307–11. https://doi.org/10.1002/(sici)1097-0339(199905)20:5<307::aid-dc12>3.0.co;2-f.
Dodd LG, Marom EM, Dash RC, Matthews MR, McLendon RE. Fine-needle aspiration cytology of "ancient" schwannoma. Diagn Cytopathol. 1999 May;20(5):307–11.
Dodd, L. G., et al. “Fine-needle aspiration cytology of "ancient" schwannoma.Diagn Cytopathol, vol. 20, no. 5, May 1999, pp. 307–11. Pubmed, doi:10.1002/(sici)1097-0339(199905)20:5<307::aid-dc12>3.0.co;2-f.
Dodd LG, Marom EM, Dash RC, Matthews MR, McLendon RE. Fine-needle aspiration cytology of "ancient" schwannoma. Diagn Cytopathol. 1999 May;20(5):307–311.
Journal cover image

Published In

Diagn Cytopathol

DOI

ISSN

8755-1039

Publication Date

May 1999

Volume

20

Issue

5

Start / End Page

307 / 311

Location

United States

Related Subject Headings

  • Pathology
  • Neurilemmoma
  • Nervous System Neoplasms
  • Middle Aged
  • Male
  • Humans
  • Female
  • Biopsy, Needle
  • Aged
  • Adult