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Outcomes of patients in clinical trials with ST-segment elevation myocardial infarction among countries with different gross national incomes.

Publication ,  Journal Article
Orlandini, A; Díaz, R; Wojdyla, D; Pieper, K; Van de Werf, F; Granger, CB; Harrington, RA; Boersma, E; Califf, RM; Armstrong, P; White, H ...
Published in: Eur Heart J
March 2006

AIMS: To evaluate whether there is an association between 30-day mortality in patients with ST-segment elevation myocardial infarction (STEMI) included in clinical trials and country gross national income (GNI). METHODS AND RESULTS: A retrospective analysis of the databases of five randomized trials including 50 310 patients with STEMI (COBALT 7169, GIK-2 2931, HERO-2 17,089, ASSENT-2 17,005, and ASSENT-3 6116 patients) from 53 countries was performed. Countries were divided into three groups according to their GNI based on the World Bank data: low (less than 2900 US dollars), medium (between 2900 US dollars and 9000 US dollars), and high GNI (more than 9000 US dollars per capita). Baseline characteristics, in-hospital management variables, and 30-day outcomes were evaluated. A previously defined logistic regression model was used to adjust for differences in baseline characteristics and to predict mortality. The observed mortality was higher than the predicted mortality in the low (12.1 vs. 11.8%) and in the medium income groups (9.4 vs. 7.9%), whereas it was lower in the high income group (4.9 vs. 5.6%). CONCLUSION: An inverse relationship between mortality and GNI was observed in STEMI clinical trials. Most of the variability in mortality can be explained by differences in baseline characteristics; however, after adjustment, lower income countries have higher mortality than the expected.

Duke Scholars

Published In

Eur Heart J

DOI

ISSN

0195-668X

Publication Date

March 2006

Volume

27

Issue

5

Start / End Page

527 / 533

Location

England

Related Subject Headings

  • Retrospective Studies
  • Regression Analysis
  • Randomized Controlled Trials as Topic
  • Prognosis
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Income
  • Humans
  • Hospitalization
 

Citation

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Orlandini, A., Díaz, R., Wojdyla, D., Pieper, K., Van de Werf, F., Granger, C. B., … Paolasso, E. (2006). Outcomes of patients in clinical trials with ST-segment elevation myocardial infarction among countries with different gross national incomes. Eur Heart J, 27(5), 527–533. https://doi.org/10.1093/eurheartj/ehi701
Orlandini, Andrés, Rafael Díaz, Daniel Wojdyla, Karen Pieper, Frans Van de Werf, Christopher B. Granger, Robert A. Harrington, et al. “Outcomes of patients in clinical trials with ST-segment elevation myocardial infarction among countries with different gross national incomes.Eur Heart J 27, no. 5 (March 2006): 527–33. https://doi.org/10.1093/eurheartj/ehi701.
Orlandini A, Díaz R, Wojdyla D, Pieper K, Van de Werf F, Granger CB, et al. Outcomes of patients in clinical trials with ST-segment elevation myocardial infarction among countries with different gross national incomes. Eur Heart J. 2006 Mar;27(5):527–33.
Orlandini, Andrés, et al. “Outcomes of patients in clinical trials with ST-segment elevation myocardial infarction among countries with different gross national incomes.Eur Heart J, vol. 27, no. 5, Mar. 2006, pp. 527–33. Pubmed, doi:10.1093/eurheartj/ehi701.
Orlandini A, Díaz R, Wojdyla D, Pieper K, Van de Werf F, Granger CB, Harrington RA, Boersma E, Califf RM, Armstrong P, White H, Simes J, Paolasso E. Outcomes of patients in clinical trials with ST-segment elevation myocardial infarction among countries with different gross national incomes. Eur Heart J. 2006 Mar;27(5):527–533.
Journal cover image

Published In

Eur Heart J

DOI

ISSN

0195-668X

Publication Date

March 2006

Volume

27

Issue

5

Start / End Page

527 / 533

Location

England

Related Subject Headings

  • Retrospective Studies
  • Regression Analysis
  • Randomized Controlled Trials as Topic
  • Prognosis
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Income
  • Humans
  • Hospitalization