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Incidence and predictors of sudden cardiac death in patients with diastolic heart failure.

Publication ,  Journal Article
Al-Khatib, SM; Shaw, LK; O'Connor, C; Kong, M; Califf, RM
Published in: J Cardiovasc Electrophysiol
December 2007

INTRODUCTION: Although it is known that patients with diastolic heart failure are at an increased risk of death, their mode of death has not been clearly defined. We conducted this study to examine the incidence and predictors of sudden cardiac death (SCD) in patients with isolated diastolic heart failure. METHODS AND RESULTS: Using the Duke Databank for Cardiovascular Disease, we identified patients with a history of congestive heart failure (CHF) and an ejection fraction of greater than 50% who were enrolled in the database from 1995 through 2004. Mode of death was adjudicated by two independent reviewers. Of the 1,941 patients who met our inclusion criteria, 548 (28%) died (40 were SCD). Using a Cox proportional hazards model, five variables were found to be independently associated with a significant increase in the risk of SCD. These variables include diabetes mellitus (P < 0.01), the presence of mild mitral regurgitation (P < 0.01), severity of CHF (P < 0.01), the occurrence of a myocardial infarction within 3 days prior to the date of the index cardiac catheterization (P = 0.01), and severity of coronary artery disease (P = 0.02). CONCLUSIONS: SCD is not uncommon in patients with isolated diastolic heart failure. We identified some clinical variables that are associated with a significant increase in the risk of SCD and that may be used in the risk stratification of patients for SCD. Studies are needed to validate our findings.

Duke Scholars

Published In

J Cardiovasc Electrophysiol

DOI

EISSN

1540-8167

Publication Date

December 2007

Volume

18

Issue

12

Start / End Page

1231 / 1235

Location

United States

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Survival Rate
  • Survival Analysis
  • Sensitivity and Specificity
  • Risk Factors
  • Risk Assessment
  • Reproducibility of Results
  • Prognosis
  • North Carolina
  • Middle Aged
 

Citation

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Al-Khatib, S. M., Shaw, L. K., O’Connor, C., Kong, M., & Califf, R. M. (2007). Incidence and predictors of sudden cardiac death in patients with diastolic heart failure. J Cardiovasc Electrophysiol, 18(12), 1231–1235. https://doi.org/10.1111/j.1540-8167.2007.00957.x
Al-Khatib, Sana M., Linda K. Shaw, Christopher O’Connor, Melissa Kong, and Robert M. Califf. “Incidence and predictors of sudden cardiac death in patients with diastolic heart failure.J Cardiovasc Electrophysiol 18, no. 12 (December 2007): 1231–35. https://doi.org/10.1111/j.1540-8167.2007.00957.x.
Al-Khatib SM, Shaw LK, O’Connor C, Kong M, Califf RM. Incidence and predictors of sudden cardiac death in patients with diastolic heart failure. J Cardiovasc Electrophysiol. 2007 Dec;18(12):1231–5.
Al-Khatib, Sana M., et al. “Incidence and predictors of sudden cardiac death in patients with diastolic heart failure.J Cardiovasc Electrophysiol, vol. 18, no. 12, Dec. 2007, pp. 1231–35. Pubmed, doi:10.1111/j.1540-8167.2007.00957.x.
Al-Khatib SM, Shaw LK, O’Connor C, Kong M, Califf RM. Incidence and predictors of sudden cardiac death in patients with diastolic heart failure. J Cardiovasc Electrophysiol. 2007 Dec;18(12):1231–1235.
Journal cover image

Published In

J Cardiovasc Electrophysiol

DOI

EISSN

1540-8167

Publication Date

December 2007

Volume

18

Issue

12

Start / End Page

1231 / 1235

Location

United States

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Survival Rate
  • Survival Analysis
  • Sensitivity and Specificity
  • Risk Factors
  • Risk Assessment
  • Reproducibility of Results
  • Prognosis
  • North Carolina
  • Middle Aged