Protection from experimental asthma by an endogenous bronchodilator.
Publication
, Journal Article
Que, LG; Liu, L; Yan, Y; Whitehead, GS; Gavett, SH; Schwartz, DA; Stamler, JS
Published in: Science
June 10, 2005
Mechanisms that protect against asthma remain poorly understood. S-nitrosoglutathione (GSNO), an endogenous bronchodilator, is depleted from asthmatic airways, suggesting a protective role. We report that, following allergen challenge, wild-type mice exhibiting airway hyperresponsivity have increased airway levels of the enzyme GSNO reductase (GSNOR) and are depleted of lung S-nitrosothiols (SNOs). In contrast, mice with genetic deletion of GSNOR exhibit increases in lung SNOs and are protected from airway hyperresponsivity. Our results indicate that endogenous SNOs, governed by GSNOR, are critical regulators of airway responsivity and may provide new therapeutic approaches to asthma.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Science
DOI
EISSN
1095-9203
Publication Date
June 10, 2005
Volume
308
Issue
5728
Start / End Page
1618 / 1621
Location
United States
Related Subject Headings
- Trachea
- S-Nitrosothiols
- S-Nitrosoglutathione
- Ovalbumin
- Nitric Oxide Synthase Type II
- Nitric Oxide Synthase
- Nitric Oxide
- Mice, Knockout
- Mice, Inbred C57BL
- Mice
Citation
APA
Chicago
ICMJE
MLA
NLM
Que, L. G., Liu, L., Yan, Y., Whitehead, G. S., Gavett, S. H., Schwartz, D. A., & Stamler, J. S. (2005). Protection from experimental asthma by an endogenous bronchodilator. Science, 308(5728), 1618–1621. https://doi.org/10.1126/science.1108228
Que, Loretta G., Limin Liu, Yun Yan, Gregory S. Whitehead, Stephen H. Gavett, David A. Schwartz, and Jonathan S. Stamler. “Protection from experimental asthma by an endogenous bronchodilator.” Science 308, no. 5728 (June 10, 2005): 1618–21. https://doi.org/10.1126/science.1108228.
Que LG, Liu L, Yan Y, Whitehead GS, Gavett SH, Schwartz DA, et al. Protection from experimental asthma by an endogenous bronchodilator. Science. 2005 Jun 10;308(5728):1618–21.
Que, Loretta G., et al. “Protection from experimental asthma by an endogenous bronchodilator.” Science, vol. 308, no. 5728, June 2005, pp. 1618–21. Pubmed, doi:10.1126/science.1108228.
Que LG, Liu L, Yan Y, Whitehead GS, Gavett SH, Schwartz DA, Stamler JS. Protection from experimental asthma by an endogenous bronchodilator. Science. 2005 Jun 10;308(5728):1618–1621.
Published In
Science
DOI
EISSN
1095-9203
Publication Date
June 10, 2005
Volume
308
Issue
5728
Start / End Page
1618 / 1621
Location
United States
Related Subject Headings
- Trachea
- S-Nitrosothiols
- S-Nitrosoglutathione
- Ovalbumin
- Nitric Oxide Synthase Type II
- Nitric Oxide Synthase
- Nitric Oxide
- Mice, Knockout
- Mice, Inbred C57BL
- Mice