Spending on postapproval drug safety.
Withdrawals of high-profile pharmaceuticals have focused attention on post-approval safety surveillance. There have been no systematic assessments of spending on postapproval safety. We surveyed drug manufacturers regarding safety efforts. Mean spending on postapproval safety per company in 2003 was 56 million dollars (0.3 percent of sales). Assuming a constant safety-to-sales ratio, we estimated that total spending on postapproval safety by the top twenty drug manufacturers was 800 million dollars in 2003. We also examined, using regression analysis, the relationship between the number of safety personnel and the number of initial adverse-event reports. This study offers information for the debate on proposed changes to safety surveillance.
Duke Scholars
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- United States
- Safety
- Regression Analysis
- Product Surveillance, Postmarketing
- Humans
- Health Policy & Services
- Drug Industry
- Drug Approval
- Costs and Cost Analysis
- 4407 Policy and administration
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- United States
- Safety
- Regression Analysis
- Product Surveillance, Postmarketing
- Humans
- Health Policy & Services
- Drug Industry
- Drug Approval
- Costs and Cost Analysis
- 4407 Policy and administration