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Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis.

Publication ,  Journal Article
Peters, KG; Coogan, A; Berry, D; Marks, J; Iglehart, JD; Kontos, CD; Rao, P; Sankar, S; Trogan, E
Published in: Br J Cancer
1998

Endothelial receptor tyrosine kinases may play important roles in pathological vascular growth, particularly in tumours. In this study, immunohistochemistry was used to evaluate the expression of a novel endothelial receptor tyrosine kinase, Tie2/Tek, in the endothelium of vascular 'hotspots' in normal breast tissue (n = 10), benign breast lesions (n = 10) and in breast tumours (n = 123). Tie2 expression was detected in the endothelium of all breast tissues examined. However, the strongest expression of Tie-2 was seen in vascular 'hot spots' within the inflammatory infiltrate at the periphery of invasive tumours. Moreover, the proportion of Tie2-positive vessels (Tie2 counts/CD31 counts) was significantly higher in breast tumours than the proportion of Tie2-positive vessels in either normal breast tissue or benign breast lesions (P = 0.004 and 0.0001 respectively). These data are consistent with a role for Tie2 in tumour angiogenesis and demonstrate the potential use of Tie2 expression as a novel marker of the tumour vasculature.

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Published In

Br J Cancer

DOI

ISSN

0007-0920

Publication Date

1998

Volume

77

Issue

1

Start / End Page

51 / 56

Location

England

Related Subject Headings

  • Receptor, TIE-2
  • Receptor Protein-Tyrosine Kinases
  • Oncology & Carcinogenesis
  • Neovascularization, Pathologic
  • Immunohistochemistry
  • Humans
  • Female
  • Endothelium, Vascular
  • Breast Neoplasms
  • Breast
 

Citation

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Peters, K. G., Coogan, A., Berry, D., Marks, J., Iglehart, J. D., Kontos, C. D., … Trogan, E. (1998). Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis. Br J Cancer, 77(1), 51–56. https://doi.org/10.1038/bjc.1998.8
Peters, K. G., A. Coogan, D. Berry, J. Marks, J. D. Iglehart, C. D. Kontos, P. Rao, S. Sankar, and E. Trogan. “Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis.Br J Cancer 77, no. 1 (1998): 51–56. https://doi.org/10.1038/bjc.1998.8.
Peters KG, Coogan A, Berry D, Marks J, Iglehart JD, Kontos CD, et al. Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis. Br J Cancer. 1998;77(1):51–6.
Peters, K. G., et al. “Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis.Br J Cancer, vol. 77, no. 1, 1998, pp. 51–56. Pubmed, doi:10.1038/bjc.1998.8.
Peters KG, Coogan A, Berry D, Marks J, Iglehart JD, Kontos CD, Rao P, Sankar S, Trogan E. Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis. Br J Cancer. 1998;77(1):51–56.

Published In

Br J Cancer

DOI

ISSN

0007-0920

Publication Date

1998

Volume

77

Issue

1

Start / End Page

51 / 56

Location

England

Related Subject Headings

  • Receptor, TIE-2
  • Receptor Protein-Tyrosine Kinases
  • Oncology & Carcinogenesis
  • Neovascularization, Pathologic
  • Immunohistochemistry
  • Humans
  • Female
  • Endothelium, Vascular
  • Breast Neoplasms
  • Breast