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Engineered transcription factors for therapeutic angiogenesis.

Publication ,  Journal Article
Kontos, CD; Annex, BH
Published in: Curr Opin Mol Ther
April 2007

Angiogenesis is defined as the growth and proliferation of blood vessels from existing vascular structures. Therapeutic angiogenesis seeks to harness the mechanisms of vascular growth to treat disorders of inadequate tissue perfusion. Early clinical trials of therapeutic angiogenesis met with limited success, in part due to the complex spatial and temporal regulation of angiogenesis, which requires the coordinate action of multiple growth factors and their receptors. Engineered transcription factors represent a novel and innovative approach to modulate this process as they offer the ability to induce expression of multiple angiogenic genes simultaneously. The rational design of these transcription factor agents, results of their use in preclinical models of ischemic disease and prospects for their use in human investigations are discussed in this review.

Duke Scholars

Published In

Curr Opin Mol Ther

ISSN

1464-8431

Publication Date

April 2007

Volume

9

Issue

2

Start / End Page

145 / 152

Location

England

Related Subject Headings

  • Vascular Endothelial Growth Factors
  • Transcription Factors
  • Neovascularization, Pathologic
  • Humans
  • Genetic Engineering
  • Clinical Trials as Topic
  • Cell Hypoxia
  • Biotechnology
  • Animals
  • 3206 Medical biotechnology
 

Citation

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ICMJE
MLA
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Kontos, C. D., & Annex, B. H. (2007). Engineered transcription factors for therapeutic angiogenesis. Curr Opin Mol Ther, 9(2), 145–152.
Kontos, Christopher D., and Brian H. Annex. “Engineered transcription factors for therapeutic angiogenesis.Curr Opin Mol Ther 9, no. 2 (April 2007): 145–52.
Kontos CD, Annex BH. Engineered transcription factors for therapeutic angiogenesis. Curr Opin Mol Ther. 2007 Apr;9(2):145–52.
Kontos, Christopher D., and Brian H. Annex. “Engineered transcription factors for therapeutic angiogenesis.Curr Opin Mol Ther, vol. 9, no. 2, Apr. 2007, pp. 145–52.
Kontos CD, Annex BH. Engineered transcription factors for therapeutic angiogenesis. Curr Opin Mol Ther. 2007 Apr;9(2):145–152.

Published In

Curr Opin Mol Ther

ISSN

1464-8431

Publication Date

April 2007

Volume

9

Issue

2

Start / End Page

145 / 152

Location

England

Related Subject Headings

  • Vascular Endothelial Growth Factors
  • Transcription Factors
  • Neovascularization, Pathologic
  • Humans
  • Genetic Engineering
  • Clinical Trials as Topic
  • Cell Hypoxia
  • Biotechnology
  • Animals
  • 3206 Medical biotechnology