Skip to main content

A randomized, prospective double-blind comparison of the efficacy of generic propofol (sulphite additive) with diprivan.

Publication ,  Journal Article
Olufolabi, AJ; Gan, TJ; Lacassie, HJ; White, WD; Habib, AS
Published in: Eur J Anaesthesiol
April 2006

BACKGROUND AND OBJECTIVE: We compared the dose requirement and side effect profile of total intravenous anaesthesia using Diprivan to generic propofol at a specific anaesthetic target level utilizing the bispectral index monitor to determine efficacy differences between the two products. METHODS: Sixty women undergoing abdominal hysterectomy were induced with propofol 2 mg kg-1 and maintained with infusion (20-200 microg kg-1 min-1) adjusted to maintain a bispectral index of 50-65. Plasma propofol concentration was measured at 1 and 2 h post induction in 25 patients. RESULTS: Mean (SD) drug doses adjusted for weight and time were similar in the Diprivan and generic propofol groups: 90 (30) microg kg-1 min-1 vs. 90 (20) microg kg-1 min-1 respectively. Mean (SD) plasma propofol levels at 1 and 2 h were also similar (3.0 (1.0) microg mL-1 vs. 3.6 (1.4) microg mL-1, P = 0.2 and 3.0 (1.9) microg mL-1 vs. 3.4 (1.6) microg mL-1, P = 0.58). CONCLUSIONS: Diprivan and generic propofol have similar efficacy at a specified, bispectral index-defined, depth of anaesthesia.

Duke Scholars

Published In

Eur J Anaesthesiol

DOI

ISSN

0265-0215

Publication Date

April 2006

Volume

23

Issue

4

Start / End Page

341 / 345

Location

England

Related Subject Headings

  • Sulfites
  • Prospective Studies
  • Propofol
  • Middle Aged
  • Hysterectomy
  • Humans
  • Female
  • Electroencephalography
  • Drugs, Generic
  • Double-Blind Method
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Olufolabi, A. J., Gan, T. J., Lacassie, H. J., White, W. D., & Habib, A. S. (2006). A randomized, prospective double-blind comparison of the efficacy of generic propofol (sulphite additive) with diprivan. Eur J Anaesthesiol, 23(4), 341–345. https://doi.org/10.1017/S0265021505001961
Olufolabi, A. J., T. J. Gan, H. J. Lacassie, W. D. White, and A. S. Habib. “A randomized, prospective double-blind comparison of the efficacy of generic propofol (sulphite additive) with diprivan.Eur J Anaesthesiol 23, no. 4 (April 2006): 341–45. https://doi.org/10.1017/S0265021505001961.
Olufolabi AJ, Gan TJ, Lacassie HJ, White WD, Habib AS. A randomized, prospective double-blind comparison of the efficacy of generic propofol (sulphite additive) with diprivan. Eur J Anaesthesiol. 2006 Apr;23(4):341–5.
Olufolabi, A. J., et al. “A randomized, prospective double-blind comparison of the efficacy of generic propofol (sulphite additive) with diprivan.Eur J Anaesthesiol, vol. 23, no. 4, Apr. 2006, pp. 341–45. Pubmed, doi:10.1017/S0265021505001961.
Olufolabi AJ, Gan TJ, Lacassie HJ, White WD, Habib AS. A randomized, prospective double-blind comparison of the efficacy of generic propofol (sulphite additive) with diprivan. Eur J Anaesthesiol. 2006 Apr;23(4):341–345.

Published In

Eur J Anaesthesiol

DOI

ISSN

0265-0215

Publication Date

April 2006

Volume

23

Issue

4

Start / End Page

341 / 345

Location

England

Related Subject Headings

  • Sulfites
  • Prospective Studies
  • Propofol
  • Middle Aged
  • Hysterectomy
  • Humans
  • Female
  • Electroencephalography
  • Drugs, Generic
  • Double-Blind Method