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A comparison of ondansetron with promethazine for treating postoperative nausea and vomiting in patients who received prophylaxis with ondansetron: a retrospective database analysis.

Publication ,  Journal Article
Habib, AS; Reuveni, J; Taguchi, A; White, WD; Gan, TJ
Published in: Anesth Analg
March 2007

BACKGROUND: There are little data on the efficacy of antiemetics for treating postoperative nausea and vomiting (PONV) in patients who received prior PONV prophylaxis. METHODS: In this retrospective database analysis, we compared the efficacy of ondansetron with that of promethazine for treating PONV in adults receiving general anesthesia who failed ondansetron prophylaxis. RESULTS: Three thousand sixty-two patients received ondansetron and 752 received promethazine after failure of ondansetron prophylaxis. The complete response (no PONV and no further rescue) was 68% after administration of promethazine and 50% after ondansetron administration (P < 0.0001). There was no difference in complete response between 6.25 mg and higher doses of promethazine. CONCLUSIONS: Promethazine was significantly more effective than ondansetron for treating PONV after failed ondansetron prophylaxis. Promethazine 6.25 mg was as effective as higher doses.

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Published In

Anesth Analg

DOI

EISSN

1526-7598

Publication Date

March 2007

Volume

104

Issue

3

Start / End Page

548 / 551

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Serotonin Antagonists
  • Retrospective Studies
  • Promethazine
  • Postoperative Nausea and Vomiting
  • Postoperative Complications
  • Ondansetron
  • Middle Aged
  • Medical Records
  • Male
 

Citation

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Habib, A. S., Reuveni, J., Taguchi, A., White, W. D., & Gan, T. J. (2007). A comparison of ondansetron with promethazine for treating postoperative nausea and vomiting in patients who received prophylaxis with ondansetron: a retrospective database analysis. Anesth Analg, 104(3), 548–551. https://doi.org/10.1213/01.ane.0000252433.73485.be
Habib, Ashraf S., Johnatan Reuveni, Akiko Taguchi, William D. White, and Tong J. Gan. “A comparison of ondansetron with promethazine for treating postoperative nausea and vomiting in patients who received prophylaxis with ondansetron: a retrospective database analysis.Anesth Analg 104, no. 3 (March 2007): 548–51. https://doi.org/10.1213/01.ane.0000252433.73485.be.
Habib, Ashraf S., et al. “A comparison of ondansetron with promethazine for treating postoperative nausea and vomiting in patients who received prophylaxis with ondansetron: a retrospective database analysis.Anesth Analg, vol. 104, no. 3, Mar. 2007, pp. 548–51. Pubmed, doi:10.1213/01.ane.0000252433.73485.be.

Published In

Anesth Analg

DOI

EISSN

1526-7598

Publication Date

March 2007

Volume

104

Issue

3

Start / End Page

548 / 551

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Serotonin Antagonists
  • Retrospective Studies
  • Promethazine
  • Postoperative Nausea and Vomiting
  • Postoperative Complications
  • Ondansetron
  • Middle Aged
  • Medical Records
  • Male