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Bootstrap calibration of TRANSMIT for informative missingness of parental genotype data.

Publication ,  Journal Article
Allen, AS; Collins, JS; Rathouz, PJ; Selander, CL; Satten, GA
Published in: BMC Genet
December 31, 2003

Informative missingness of parental genotype data occurs when the genotype of a parent influences the probability of the parent's genotype data being observed. Informative missingness can occur in a number of plausible ways and can affect both the validity and power of procedures that assume the data are missing at random (MAR). We propose a bootstrap calibration of MAR procedures to account for informative missingness and apply our methodology to refine the approach implemented in the TRANSMIT program. We illustrate this approach by applying it to data on hypertensive probands and their parents who participated in the Framingham Heart Study.

Duke Scholars

Published In

BMC Genet

DOI

EISSN

1471-2156

Publication Date

December 31, 2003

Volume

4 Suppl 1

Issue

Suppl 1

Start / End Page

S39

Location

England

Related Subject Headings

  • Software
  • Quantitative Trait, Heritable
  • Parents
  • Models, Statistical
  • Male
  • Humans
  • Genotype
  • Genetics & Heredity
  • Female
  • Factor Analysis, Statistical
 

Citation

APA
Chicago
ICMJE
MLA
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Allen, A. S., Collins, J. S., Rathouz, P. J., Selander, C. L., & Satten, G. A. (2003). Bootstrap calibration of TRANSMIT for informative missingness of parental genotype data. BMC Genet, 4 Suppl 1(Suppl 1), S39. https://doi.org/10.1186/1471-2156-4-S1-S39
Allen, Andrew S., Julianne S. Collins, Paul J. Rathouz, Craig L. Selander, and Glen A. Satten. “Bootstrap calibration of TRANSMIT for informative missingness of parental genotype data.BMC Genet 4 Suppl 1, no. Suppl 1 (December 31, 2003): S39. https://doi.org/10.1186/1471-2156-4-S1-S39.
Allen AS, Collins JS, Rathouz PJ, Selander CL, Satten GA. Bootstrap calibration of TRANSMIT for informative missingness of parental genotype data. BMC Genet. 2003 Dec 31;4 Suppl 1(Suppl 1):S39.
Allen, Andrew S., et al. “Bootstrap calibration of TRANSMIT for informative missingness of parental genotype data.BMC Genet, vol. 4 Suppl 1, no. Suppl 1, Dec. 2003, p. S39. Pubmed, doi:10.1186/1471-2156-4-S1-S39.
Allen AS, Collins JS, Rathouz PJ, Selander CL, Satten GA. Bootstrap calibration of TRANSMIT for informative missingness of parental genotype data. BMC Genet. 2003 Dec 31;4 Suppl 1(Suppl 1):S39.
Journal cover image

Published In

BMC Genet

DOI

EISSN

1471-2156

Publication Date

December 31, 2003

Volume

4 Suppl 1

Issue

Suppl 1

Start / End Page

S39

Location

England

Related Subject Headings

  • Software
  • Quantitative Trait, Heritable
  • Parents
  • Models, Statistical
  • Male
  • Humans
  • Genotype
  • Genetics & Heredity
  • Female
  • Factor Analysis, Statistical