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Ovarian hyperstimulation in polycystic ovary syndrome during therapy with leuprolide acetate.

Publication ,  Journal Article
Walmer, DK; Haney, AF; Dodson, WC
Published in: Fertility and sterility
November 1989

Continuous exposure to GnRH eliminates the pituitary as a source of gonadotropins and may have direct suppressive effects on the ovary. A woman with PCO syndrome received leuprolide acetate (1 mg/d SC) for 4 weeks before and simultaneously with hMG stimulation. Human chorionic gonadotropin (5,000 IU) was administered IM on the 8th day of hMG therapy. There were 10 follicles greater than 15 mm and a polycystic appearance to the ovaries with 25 follicles measuring less than 10 mm. The serum E2 concentration was 2,280 pg/mL. She developed severe ovarian hyperstimulation and required hospitalization for 12 days for fluid management. A viable intrauterine pregnancy was present. Four weeks of pretreatment with leuprolide did not prevent hyperstimulation in the presence of an intrauterine pregnancy.

Duke Scholars

Published In

Fertility and sterility

DOI

EISSN

1556-5653

ISSN

0015-0282

Publication Date

November 1989

Volume

52

Issue

5

Start / End Page

858 / 859

Related Subject Headings

  • Stimulation, Chemical
  • Pregnancy
  • Polycystic Ovary Syndrome
  • Ovulation Induction
  • Ovary
  • Obstetrics & Reproductive Medicine
  • Menotropins
  • Leuprolide
  • Humans
  • Hormones
 

Citation

APA
Chicago
ICMJE
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Walmer, D. K., Haney, A. F., & Dodson, W. C. (1989). Ovarian hyperstimulation in polycystic ovary syndrome during therapy with leuprolide acetate. Fertility and Sterility, 52(5), 858–859. https://doi.org/10.1016/s0015-0282(16)53053-2
Walmer, D. K., A. F. Haney, and W. C. Dodson. “Ovarian hyperstimulation in polycystic ovary syndrome during therapy with leuprolide acetate.Fertility and Sterility 52, no. 5 (November 1989): 858–59. https://doi.org/10.1016/s0015-0282(16)53053-2.
Walmer DK, Haney AF, Dodson WC. Ovarian hyperstimulation in polycystic ovary syndrome during therapy with leuprolide acetate. Fertility and sterility. 1989 Nov;52(5):858–9.
Walmer, D. K., et al. “Ovarian hyperstimulation in polycystic ovary syndrome during therapy with leuprolide acetate.Fertility and Sterility, vol. 52, no. 5, Nov. 1989, pp. 858–59. Epmc, doi:10.1016/s0015-0282(16)53053-2.
Walmer DK, Haney AF, Dodson WC. Ovarian hyperstimulation in polycystic ovary syndrome during therapy with leuprolide acetate. Fertility and sterility. 1989 Nov;52(5):858–859.
Journal cover image

Published In

Fertility and sterility

DOI

EISSN

1556-5653

ISSN

0015-0282

Publication Date

November 1989

Volume

52

Issue

5

Start / End Page

858 / 859

Related Subject Headings

  • Stimulation, Chemical
  • Pregnancy
  • Polycystic Ovary Syndrome
  • Ovulation Induction
  • Ovary
  • Obstetrics & Reproductive Medicine
  • Menotropins
  • Leuprolide
  • Humans
  • Hormones