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Hepatitis C.

Publication ,  Journal Article
Sharara, AI; Hunt, CM; Hamilton, JD
Published in: Ann Intern Med
October 15, 1996

OBJECTIVES: To review the virology, epidemiology, pathogenesis, natural history, clinical manifestations, and current treatment of hepatitis C virus (HCV) infection. DATA SOURCES: The MEDLINE database (1966 to 1996) was searched for English-language articles and abstracts on HCV and non-A, non-B hepatitis. Papers cited in relevant primary articles were also reviewed. STUDY SELECTION: More than 500 original and review articles were evaluated, and the most relevant were selected. DATA EXTRACTION: Data were extracted and reviewed by all authors. DATA SYNTHESIS: In most patients, HCV infection results in chronic hepatitis. The disease is insidious and subclinical but may progress over decades into end-stage liver disease and hepatocellular carcinoma, which makes HCV cirrhosis a leading indication for orthotopic liver transplantation. Current diagnostic methods are highly sensitive and specific, and quantitative assessment of viral load may help to predict and monitor response to treatment. The only available therapeutic option is interferon, and this agent is effective in only a small subset of patients. CONCLUSIONS: Infection with HCV is a significant public health problem that has important clinical and financial consequences. The tailoring of specific therapy according to viral load or genotype, better patient selection, and use of combination drug regimens may improve the chance of viral clearance and sustained biochemical and histologic response. Further understanding of the basic virology of HCV and the exact mechanisms of viral persistence and tissue injury is needed to help define future therapeutic and preventive strategies.

Duke Scholars

Published In

Ann Intern Med

DOI

ISSN

0003-4819

Publication Date

October 15, 1996

Volume

125

Issue

8

Start / End Page

658 / 668

Location

United States

Related Subject Headings

  • United States
  • Liver Transplantation
  • Liver Neoplasms
  • Liver Failure
  • Interferons
  • Humans
  • Hepatitis C
  • General & Internal Medicine
  • Carcinoma, Hepatocellular
  • 3202 Clinical sciences
 

Citation

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MLA
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Sharara, A. I., Hunt, C. M., & Hamilton, J. D. (1996). Hepatitis C. Ann Intern Med, 125(8), 658–668. https://doi.org/10.7326/0003-4819-125-8-199610150-00006
Sharara, A. I., C. M. Hunt, and J. D. Hamilton. “Hepatitis C.Ann Intern Med 125, no. 8 (October 15, 1996): 658–68. https://doi.org/10.7326/0003-4819-125-8-199610150-00006.
Sharara AI, Hunt CM, Hamilton JD. Hepatitis C. Ann Intern Med. 1996 Oct 15;125(8):658–68.
Sharara, A. I., et al. “Hepatitis C.Ann Intern Med, vol. 125, no. 8, Oct. 1996, pp. 658–68. Pubmed, doi:10.7326/0003-4819-125-8-199610150-00006.
Sharara AI, Hunt CM, Hamilton JD. Hepatitis C. Ann Intern Med. 1996 Oct 15;125(8):658–668.

Published In

Ann Intern Med

DOI

ISSN

0003-4819

Publication Date

October 15, 1996

Volume

125

Issue

8

Start / End Page

658 / 668

Location

United States

Related Subject Headings

  • United States
  • Liver Transplantation
  • Liver Neoplasms
  • Liver Failure
  • Interferons
  • Humans
  • Hepatitis C
  • General & Internal Medicine
  • Carcinoma, Hepatocellular
  • 3202 Clinical sciences