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Brain abscess caused by a variety of cladosporium trichoides.

Publication ,  Journal Article
Seaworth, BJ; Kwon-Chung, KJ; Hamilton, JD; Perfect, JR
Published in: Am J Clin Pathol
June 1983

A brain abscess caused by a new variety of Cladosporium trichoides occurred in a previously healthy man. A reversed T-suppressor/helper cell ratio was noted as the only immunologic abnormality. He required three surgical procedures, the last an occipital lobectomy, and antifungal chemotherapy to control his disease. He received 2,068 mg of amphotericin B and one year of flucytosine at 6 g per day. Ten months after the last surgery he is without evidence of disease. C. trichoides var. chlamydosporum was isolated from the abscess. It differed from C. trichoides by producing chlamydospores in vitro and only hyphae in the brain abscess. On modified Sabouraud agar, the fungus did not grow at 25 degrees C and grew poorly at 30 degrees C and 37 degrees C. Histologic sections revealed necrosis, no encapsulation, and no epitheliod cells.

Duke Scholars

Published In

Am J Clin Pathol

DOI

ISSN

0002-9173

Publication Date

June 1983

Volume

79

Issue

6

Start / End Page

747 / 752

Location

England

Related Subject Headings

  • T-Lymphocytes, Regulatory
  • T-Lymphocytes, Helper-Inducer
  • Pathology
  • Mycoses
  • Mitosporic Fungi
  • Middle Aged
  • Male
  • Humans
  • Flucytosine
  • Cladosporium
 

Citation

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Seaworth, B. J., Kwon-Chung, K. J., Hamilton, J. D., & Perfect, J. R. (1983). Brain abscess caused by a variety of cladosporium trichoides. Am J Clin Pathol, 79(6), 747–752. https://doi.org/10.1093/ajcp/79.6.747
Seaworth, B. J., K. J. Kwon-Chung, J. D. Hamilton, and J. R. Perfect. “Brain abscess caused by a variety of cladosporium trichoides.Am J Clin Pathol 79, no. 6 (June 1983): 747–52. https://doi.org/10.1093/ajcp/79.6.747.
Seaworth BJ, Kwon-Chung KJ, Hamilton JD, Perfect JR. Brain abscess caused by a variety of cladosporium trichoides. Am J Clin Pathol. 1983 Jun;79(6):747–52.
Seaworth, B. J., et al. “Brain abscess caused by a variety of cladosporium trichoides.Am J Clin Pathol, vol. 79, no. 6, June 1983, pp. 747–52. Pubmed, doi:10.1093/ajcp/79.6.747.
Seaworth BJ, Kwon-Chung KJ, Hamilton JD, Perfect JR. Brain abscess caused by a variety of cladosporium trichoides. Am J Clin Pathol. 1983 Jun;79(6):747–752.
Journal cover image

Published In

Am J Clin Pathol

DOI

ISSN

0002-9173

Publication Date

June 1983

Volume

79

Issue

6

Start / End Page

747 / 752

Location

England

Related Subject Headings

  • T-Lymphocytes, Regulatory
  • T-Lymphocytes, Helper-Inducer
  • Pathology
  • Mycoses
  • Mitosporic Fungi
  • Middle Aged
  • Male
  • Humans
  • Flucytosine
  • Cladosporium