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Determinants of the source of cytomegalovirus in murine renal allograft recipients.

Publication ,  Journal Article
Klotman, ME; Henry, SC; Hamilton, JD
Published in: Transplantation
November 1987

Cytomegalovirus is present in a latent state in renal allografts and may be reactivated in recipients. While human and murine strains are alike in that a primary infection occurs in seronegative recipients of a kidney from a seropositive donor, they may differ when the recipient is seropositive. In a murine transplant model, superinfection of a seropositive recipient with a second strain is unusual. Reports in human transplantation indicate that superinfection of a seropositive recipient does occur, however the frequency is unknown. Our studies examine the potential importance of specific viral strains in host and recipient, the contribution of prior humoral immunity in the recipient, and the technical ability to identify distinctive strains of virus in the presence of each other. Our results indicate that reversal of the viral strains in donor or recipient animals does not alter our previous observation that reactivation of the endogenous recipient viral strain predominates as the infecting strain in the posttransplant period. Further, the presence of antibody in nearly all donors and recipients confirms that all animals were originally infected prior to transplantation. Finally, we demonstrated the technical ability to detect one virus in the presence of the other, thus excluding this variable as possibly confounding. We conclude that the endogenous, latent recipient strain of cytomegalovirus in the murine model is preferentially reactivated in the posttransplant interval.

Duke Scholars

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

November 1987

Volume

44

Issue

5

Start / End Page

636 / 639

Location

United States

Related Subject Headings

  • Surgery
  • Species Specificity
  • Postoperative Complications
  • Mice, Inbred BALB C
  • Mice
  • Kidney Transplantation
  • DNA, Viral
  • DNA Restriction Enzymes
  • Cytomegalovirus Infections
  • Cytomegalovirus
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Klotman, M. E., Henry, S. C., & Hamilton, J. D. (1987). Determinants of the source of cytomegalovirus in murine renal allograft recipients. Transplantation, 44(5), 636–639. https://doi.org/10.1097/00007890-198711000-00008
Klotman, M. E., S. C. Henry, and J. D. Hamilton. “Determinants of the source of cytomegalovirus in murine renal allograft recipients.Transplantation 44, no. 5 (November 1987): 636–39. https://doi.org/10.1097/00007890-198711000-00008.
Klotman ME, Henry SC, Hamilton JD. Determinants of the source of cytomegalovirus in murine renal allograft recipients. Transplantation. 1987 Nov;44(5):636–9.
Klotman, M. E., et al. “Determinants of the source of cytomegalovirus in murine renal allograft recipients.Transplantation, vol. 44, no. 5, Nov. 1987, pp. 636–39. Pubmed, doi:10.1097/00007890-198711000-00008.
Klotman ME, Henry SC, Hamilton JD. Determinants of the source of cytomegalovirus in murine renal allograft recipients. Transplantation. 1987 Nov;44(5):636–639.

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

November 1987

Volume

44

Issue

5

Start / End Page

636 / 639

Location

United States

Related Subject Headings

  • Surgery
  • Species Specificity
  • Postoperative Complications
  • Mice, Inbred BALB C
  • Mice
  • Kidney Transplantation
  • DNA, Viral
  • DNA Restriction Enzymes
  • Cytomegalovirus Infections
  • Cytomegalovirus